The effect of increasing fibrinolysis in patients with rheumatoid arthritis

a double blind study of stanozolol

J. J. Belch, R. Madhok, B. McArdle, K. McLaughlin, C. Kluft, C. D. Forbes, R. D. Sturrock

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    Abstract

    Fibrin deposition in rheumatoid arthritis may be responsible for some of the clinical manifestations of the disease. It has been shown that in severe rheumatoid arthritis fibrinolysis is decreased but can be stimulated using the fibrinolytic enhancing agent stanozolol. A prolonged increase in fibrinolysis may decrease joint fibrin deposition and lead to clinical improvement and we have therefore investigated stanozolol as a therapeutic agent. Forty patients were enrolled. Twenty patients received stanozolol 5 mg twice daily for six months and 20 received a matching placebo. Assessment of disease activity was made in the conventional way. Results show that the two groups were comparable. After six months nine of the control patients had withdrawn because of drug ineffectiveness compared with two stanozolol patients, and five control patients felt they had improved compared with 15 stanozolol patients. Disease activity had significantly decreased by the end of the study in the treated group, and detailed analysis showed improvement in ESR, articular index, duration of morning stiffness and visual analogue pain scale. We suggest that stanozolol may be of value in rheumatoid arthritis although this pilot study has looked at only small numbers of patients over a short period.
    Original languageEnglish
    Pages (from-to)19-27
    Number of pages9
    JournalQuarterly Journal of Medicine
    Volume58
    Issue number1
    Publication statusPublished - 1986

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    Stanozolol
    Fibrinolysis
    Double-Blind Method
    Rheumatoid Arthritis
    Fibrin
    Joints
    Fibrinolytic Agents
    Pain Measurement
    Placebos

    Cite this

    Belch, J. J., Madhok, R., McArdle, B., McLaughlin, K., Kluft, C., Forbes, C. D., & Sturrock, R. D. (1986). The effect of increasing fibrinolysis in patients with rheumatoid arthritis: a double blind study of stanozolol. Quarterly Journal of Medicine, 58(1), 19-27.
    Belch, J. J. ; Madhok, R. ; McArdle, B. ; McLaughlin, K. ; Kluft, C. ; Forbes, C. D. ; Sturrock, R. D. / The effect of increasing fibrinolysis in patients with rheumatoid arthritis : a double blind study of stanozolol. In: Quarterly Journal of Medicine. 1986 ; Vol. 58, No. 1. pp. 19-27.
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    abstract = "Fibrin deposition in rheumatoid arthritis may be responsible for some of the clinical manifestations of the disease. It has been shown that in severe rheumatoid arthritis fibrinolysis is decreased but can be stimulated using the fibrinolytic enhancing agent stanozolol. A prolonged increase in fibrinolysis may decrease joint fibrin deposition and lead to clinical improvement and we have therefore investigated stanozolol as a therapeutic agent. Forty patients were enrolled. Twenty patients received stanozolol 5 mg twice daily for six months and 20 received a matching placebo. Assessment of disease activity was made in the conventional way. Results show that the two groups were comparable. After six months nine of the control patients had withdrawn because of drug ineffectiveness compared with two stanozolol patients, and five control patients felt they had improved compared with 15 stanozolol patients. Disease activity had significantly decreased by the end of the study in the treated group, and detailed analysis showed improvement in ESR, articular index, duration of morning stiffness and visual analogue pain scale. We suggest that stanozolol may be of value in rheumatoid arthritis although this pilot study has looked at only small numbers of patients over a short period.",
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    Belch, JJ, Madhok, R, McArdle, B, McLaughlin, K, Kluft, C, Forbes, CD & Sturrock, RD 1986, 'The effect of increasing fibrinolysis in patients with rheumatoid arthritis: a double blind study of stanozolol', Quarterly Journal of Medicine, vol. 58, no. 1, pp. 19-27.

    The effect of increasing fibrinolysis in patients with rheumatoid arthritis : a double blind study of stanozolol. / Belch, J. J.; Madhok, R.; McArdle, B.; McLaughlin, K.; Kluft, C.; Forbes, C. D.; Sturrock, R. D.

    In: Quarterly Journal of Medicine, Vol. 58, No. 1, 1986, p. 19-27.

    Research output: Contribution to journalArticle

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    T1 - The effect of increasing fibrinolysis in patients with rheumatoid arthritis

    T2 - a double blind study of stanozolol

    AU - Belch, J. J.

    AU - Madhok, R.

    AU - McArdle, B.

    AU - McLaughlin, K.

    AU - Kluft, C.

    AU - Forbes, C. D.

    AU - Sturrock, R. D.

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    N2 - Fibrin deposition in rheumatoid arthritis may be responsible for some of the clinical manifestations of the disease. It has been shown that in severe rheumatoid arthritis fibrinolysis is decreased but can be stimulated using the fibrinolytic enhancing agent stanozolol. A prolonged increase in fibrinolysis may decrease joint fibrin deposition and lead to clinical improvement and we have therefore investigated stanozolol as a therapeutic agent. Forty patients were enrolled. Twenty patients received stanozolol 5 mg twice daily for six months and 20 received a matching placebo. Assessment of disease activity was made in the conventional way. Results show that the two groups were comparable. After six months nine of the control patients had withdrawn because of drug ineffectiveness compared with two stanozolol patients, and five control patients felt they had improved compared with 15 stanozolol patients. Disease activity had significantly decreased by the end of the study in the treated group, and detailed analysis showed improvement in ESR, articular index, duration of morning stiffness and visual analogue pain scale. We suggest that stanozolol may be of value in rheumatoid arthritis although this pilot study has looked at only small numbers of patients over a short period.

    AB - Fibrin deposition in rheumatoid arthritis may be responsible for some of the clinical manifestations of the disease. It has been shown that in severe rheumatoid arthritis fibrinolysis is decreased but can be stimulated using the fibrinolytic enhancing agent stanozolol. A prolonged increase in fibrinolysis may decrease joint fibrin deposition and lead to clinical improvement and we have therefore investigated stanozolol as a therapeutic agent. Forty patients were enrolled. Twenty patients received stanozolol 5 mg twice daily for six months and 20 received a matching placebo. Assessment of disease activity was made in the conventional way. Results show that the two groups were comparable. After six months nine of the control patients had withdrawn because of drug ineffectiveness compared with two stanozolol patients, and five control patients felt they had improved compared with 15 stanozolol patients. Disease activity had significantly decreased by the end of the study in the treated group, and detailed analysis showed improvement in ESR, articular index, duration of morning stiffness and visual analogue pain scale. We suggest that stanozolol may be of value in rheumatoid arthritis although this pilot study has looked at only small numbers of patients over a short period.

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