The effect of radiological contrast media on renal function and inflammatory markers in people with diabetes - A clinical study and review

Mark Baxter; Catherine Gooday; Ketan Dhatariya

doi:10.15277/bjdvd.2015.040

The effect of radiological contrast media on renal function and inflammatory markers in people with diabetes - A clinical study and review

Mark Baxter
, Catherine Gooday
, Ketan Dhatariya (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To assess the association of inflammatory markers and the risk of developing contrast-induced nephropathy (CIN) in patients with diabetes undergoing lower limb angiography.
Methods: This was a retrospective study of 77 patients undergoing lower limb angiography. We measured renal function and markers of inflammation, in particular neutrophil and lymphocyte count and C-reactive protein (CRP) levels, before and at 24, 48 and 72 hours after administration of contrast medium.
Results: Those with pre-existing renal disease were at increased risk of CIN. We found no relationship between baseline renal function and CRP. There was a reduction in haemoglobin and lymphocyte count that is currently unexplained.
Conclusions: While several traditional risk factors for CIN have been identified, further work is needed to determine the significance of changes in other haematological parameters.

Original language	English
Pages (from-to)	187-191
Number of pages	5
Journal	The British Journal of Diabetes & Vascular Disease
Volume	15
Issue number	4
DOIs	https://doi.org/10.15277/bjdvd.2015.040
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

diabetes
angiography
contrast
contrast-induced nephropathy
inflammatory markers

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10.15277/bjdvd.2015.040

Cite this

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title = "The effect of radiological contrast media on renal function and inflammatory markers in people with diabetes - A clinical study and review",

abstract = "Aim: To assess the association of inflammatory markers and the risk of developing contrast-induced nephropathy (CIN) in patients with diabetes undergoing lower limb angiography. Methods: This was a retrospective study of 77 patients undergoing lower limb angiography. We measured renal function and markers of inflammation, in particular neutrophil and lymphocyte count and C-reactive protein (CRP) levels, before and at 24, 48 and 72 hours after administration of contrast medium. Results: Those with pre-existing renal disease were at increased risk of CIN. We found no relationship between baseline renal function and CRP. There was a reduction in haemoglobin and lymphocyte count that is currently unexplained. Conclusions: While several traditional risk factors for CIN have been identified, further work is needed to determine the significance of changes in other haematological parameters.",

keywords = "diabetes, angiography, contrast, contrast-induced nephropathy, inflammatory markers",

author = "Mark Baxter and Catherine Gooday and Ketan Dhatariya",

year = "2015",

doi = "10.15277/bjdvd.2015.040",

language = "English",

volume = "15",

pages = "187--191",

journal = "The British Journal of Diabetes \& Vascular Disease",

issn = "1753-4305",

publisher = "SAGE Publications",

number = "4",

}

The effect of radiological contrast media on renal function and inflammatory markers in people with diabetes - A clinical study and review. / Baxter, Mark; Gooday, Catherine; Dhatariya, Ketan (Lead / Corresponding author).
In: The British Journal of Diabetes & Vascular Disease, Vol. 15, No. 4, 2015, p. 187-191.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The effect of radiological contrast media on renal function and inflammatory markers in people with diabetes - A clinical study and review

AU - Baxter, Mark

AU - Gooday, Catherine

AU - Dhatariya, Ketan

PY - 2015

Y1 - 2015

N2 - Aim: To assess the association of inflammatory markers and the risk of developing contrast-induced nephropathy (CIN) in patients with diabetes undergoing lower limb angiography. Methods: This was a retrospective study of 77 patients undergoing lower limb angiography. We measured renal function and markers of inflammation, in particular neutrophil and lymphocyte count and C-reactive protein (CRP) levels, before and at 24, 48 and 72 hours after administration of contrast medium. Results: Those with pre-existing renal disease were at increased risk of CIN. We found no relationship between baseline renal function and CRP. There was a reduction in haemoglobin and lymphocyte count that is currently unexplained. Conclusions: While several traditional risk factors for CIN have been identified, further work is needed to determine the significance of changes in other haematological parameters.

AB - Aim: To assess the association of inflammatory markers and the risk of developing contrast-induced nephropathy (CIN) in patients with diabetes undergoing lower limb angiography. Methods: This was a retrospective study of 77 patients undergoing lower limb angiography. We measured renal function and markers of inflammation, in particular neutrophil and lymphocyte count and C-reactive protein (CRP) levels, before and at 24, 48 and 72 hours after administration of contrast medium. Results: Those with pre-existing renal disease were at increased risk of CIN. We found no relationship between baseline renal function and CRP. There was a reduction in haemoglobin and lymphocyte count that is currently unexplained. Conclusions: While several traditional risk factors for CIN have been identified, further work is needed to determine the significance of changes in other haematological parameters.

KW - diabetes

KW - angiography

KW - contrast

KW - contrast-induced nephropathy

KW - inflammatory markers

U2 - 10.15277/bjdvd.2015.040

DO - 10.15277/bjdvd.2015.040

M3 - Article

SN - 1753-4305

VL - 15

SP - 187

EP - 191

JO - The British Journal of Diabetes & Vascular Disease

JF - The British Journal of Diabetes & Vascular Disease

IS - 4

ER -

The effect of radiological contrast media on renal function and inflammatory markers in people with diabetes - A clinical study and review

Abstract

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Keywords

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