The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides

G McDowell; W Coutie; C Shaw; K. D. Buchanan; A D Struthers; D P Nicholls

doi:10.1046/j.1365-2125.1997.00545.x

The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides

G McDowell, W Coutie, C Shaw, K. D. Buchanan, A D Struthers, D P Nicholls

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Candoxatril is a specific neutral endopeptidase (NEP) 24.11 inhibitor, and previous work has documented the effect of NEP inhibition on atrial and brain natriuretic peptides (ANP, BNP). The aim of the present study was to ascertain the effect of NEP inhibition on circulating levels of vasoactive peptides.

Original language	English
Pages (from-to)	329-332
Number of pages	4
Journal	British Journal of Clinical Pharmacology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2125.1997.00545.x
Publication status	Published - 1997

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10.1046/j.1365-2125.1997.00545.x

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title = "The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides",

abstract = "Candoxatril is a specific neutral endopeptidase (NEP) 24.11 inhibitor, and previous work has documented the effect of NEP inhibition on atrial and brain natriuretic peptides (ANP, BNP). The aim of the present study was to ascertain the effect of NEP inhibition on circulating levels of vasoactive peptides.",

author = "G McDowell and W Coutie and C Shaw and Buchanan, {K. D.} and Struthers, {A D} and Nicholls, {D P}",

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AU - McDowell, G

AU - Coutie, W

AU - Shaw, C

AU - Buchanan, K. D.

AU - Struthers, A D

AU - Nicholls, D P

PY - 1997

Y1 - 1997

N2 - Candoxatril is a specific neutral endopeptidase (NEP) 24.11 inhibitor, and previous work has documented the effect of NEP inhibition on atrial and brain natriuretic peptides (ANP, BNP). The aim of the present study was to ascertain the effect of NEP inhibition on circulating levels of vasoactive peptides.

AB - Candoxatril is a specific neutral endopeptidase (NEP) 24.11 inhibitor, and previous work has documented the effect of NEP inhibition on atrial and brain natriuretic peptides (ANP, BNP). The aim of the present study was to ascertain the effect of NEP inhibition on circulating levels of vasoactive peptides.

U2 - 10.1046/j.1365-2125.1997.00545.x

DO - 10.1046/j.1365-2125.1997.00545.x

M3 - Article

C2 - 9088591

SN - 0306-5251

VL - 43

SP - 329

EP - 332

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 3

ER -

The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides

Abstract

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