Candoxatril is a specific neutral endopeptidase (NEP) 24.11 inhibitor, and previous work has documented the effect of NEP inhibition on atrial and brain natriuretic peptides (ANP, BNP). The aim of the present study was to ascertain the effect of NEP inhibition on circulating levels of vasoactive peptides.
McDowell, G., Coutie, W., Shaw, C., Buchanan, K. D., Struthers, A. D., & Nicholls, D. P. (1997). The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides. British Journal of Clinical Pharmacology, 43(3), 329-332. https://doi.org/10.1046/j.1365-2125.1997.00545.x