The effect of topical indomethacin on ultraviolet-radiation-induced erythema

S. H. Ibbotson, B. L. Diffey, P. M. Farr

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Indomethacin inhibits UVB erythema but is thought not to influence UVA erythema. We have examined the wavelength dependence of the effect of indomethacin on ultraviolet radiation (UVR) erythema. Duplicate sites on the back were irradiated with a series of doses at 300 and 320 nm, or single doses at 330, 340, 350 or 370 nm. Indomethacin 1% was applied to sites on one side of the back after irradiation, occluded for 2h and erythema measured at 24h with a reflectance instrument. Indomethacin inhibited 300 and 320 nm (UVB) erythema, had no effect at 330 and 340 nm (UVA2), but augmented 350 and 370 nm (UVA1) erythema. There appears to be a varied response of UVR erythema to cyclo-oxygenase inhibition at different wavelengths across the UVR spectrum. This mechanism may be deranged in certain photosensitive disorders.
    Original languageEnglish
    Pages (from-to)523-527
    Number of pages5
    JournalBritish Journal of Dermatology
    Volume135
    Issue number4
    DOIs
    Publication statusPublished - Oct 1996

    Keywords

    • Ultraviolet Rays
    • Erythema
    • Humans
    • Cyclooxygenase Inhibitors
    • Aged
    • Dose-Response Relationship, Radiation
    • Aged, 80 and over
    • Adult
    • Indomethacin
    • Anti-Inflammatory Agents, Non-Steroidal
    • Middle Aged
    • Female
    • Male
    • Radiation Injuries

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