The effect of urea and taurine as hydrophilic penetration enhancers on stratum corneum lipid models

J. Mueller, J. S L Oliveira, R. Barker, M. Trapp, A. Schroeter, G. Brezesinski (Lead / Corresponding author), R. H H Neubert (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


To optimize transdermal application of drugs, the barrier function of the skin, especially the stratum corneum (SC), needs to be reduced reversibly. For this purpose, penetration enhancers like urea or taurine are applied. Until now, it is unclear if this penetration enhancement is caused by an interaction with the SC lipid matrix or related to effects within the corneocytes. Therefore, the effects of both hydrophilic enhancers on SC models with different dimensionality, ranging from monolayers to multilayers, have been investigated in this study. Many sophisticated methods were applied to ascertain the mode of action of both substances on a molecular scale. The experiments reveal that there is no specific interaction when 10% urea or 5% taurine solutions are added to the SC model systems. No additional water uptake in the head group region and no decrease of the lipid chain packing density have been observed. Consequently, we suppose that the penetration enhancing effect of both substances might be based on the introduction of large amounts of water into the corneocytes, caused by the enormous water binding capacity of urea and a resulting osmotic pressure in case of taurine.

Original languageEnglish
Pages (from-to)2006-2018
Number of pages13
JournalBBA - Biomembranes
Issue number9
Early online date16 May 2016
Publication statusPublished - Sept 2016


  • Mode of action
  • Model membrane
  • Penetration enhancer
  • Stratum corneum lipids
  • Transdermal drug delivery

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biophysics


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