The effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in habitual smokers

J. J. F. Belch, B. M. McArdle, P. Burns, G. D. O. Lowe, C. D. Forbes

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    Abstract

    There is an increased frequency of arterial thrombosis in cigarette smokers. The changes in blood coagulation seen in these subjects have been studied by many workers but results have not always been in agreement. We wished to study the effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in ten habitual smokers, and to compare these results with non-smoking controls. Results show that the smoking group had higher plasma fibrinogen (p less than 0.04), lower plasminogen (p less than 0.02) and plasminogen activator (p less than 0.05), and higher plasma viscosity (p less than 0.003). The changes seen in cigarette smokers after smoking three cigarettes were an increase in the rate of platelet aggregation to ADP (p less than 0.02), an increase in alpha 2M, (p less than 0.02), and factor VIII RAG (p less than 0.05). Plasma viscosity was decreased (p less than 0.02) as was red cell deformability (p less than 0.02). We confirm an increased tendency to hypercoagulability in smokers compared to controls which becomes more pronounced immediately after smoking three cigarettes.
    Original languageEnglish
    Pages (from-to)6-8
    Number of pages3
    JournalThrombosis and Haemostasis
    Volume51
    Issue number1
    Publication statusPublished - 1984

    Fingerprint

    Hemorheology
    Fibrinolysis
    Blood Platelets
    Smoking
    Viscosity
    Tobacco Products
    Thrombophilia
    Plasminogen Activators
    Plasminogen
    Factor VIII
    Blood Coagulation
    Platelet Aggregation
    Adenosine Diphosphate
    Fibrinogen
    Thrombosis

    Cite this

    Belch, J. J. F. ; McArdle, B. M. ; Burns, P. ; Lowe, G. D. O. ; Forbes, C. D. / The effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in habitual smokers. In: Thrombosis and Haemostasis. 1984 ; Vol. 51, No. 1. pp. 6-8.
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    abstract = "There is an increased frequency of arterial thrombosis in cigarette smokers. The changes in blood coagulation seen in these subjects have been studied by many workers but results have not always been in agreement. We wished to study the effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in ten habitual smokers, and to compare these results with non-smoking controls. Results show that the smoking group had higher plasma fibrinogen (p less than 0.04), lower plasminogen (p less than 0.02) and plasminogen activator (p less than 0.05), and higher plasma viscosity (p less than 0.003). The changes seen in cigarette smokers after smoking three cigarettes were an increase in the rate of platelet aggregation to ADP (p less than 0.02), an increase in alpha 2M, (p less than 0.02), and factor VIII RAG (p less than 0.05). Plasma viscosity was decreased (p less than 0.02) as was red cell deformability (p less than 0.02). We confirm an increased tendency to hypercoagulability in smokers compared to controls which becomes more pronounced immediately after smoking three cigarettes.",
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    year = "1984",
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    The effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in habitual smokers. / Belch, J. J. F.; McArdle, B. M.; Burns, P.; Lowe, G. D. O.; Forbes, C. D.

    In: Thrombosis and Haemostasis, Vol. 51, No. 1, 1984, p. 6-8.

    Research output: Contribution to journalArticle

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    T1 - The effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in habitual smokers

    AU - Belch, J. J. F.

    AU - McArdle, B. M.

    AU - Burns, P.

    AU - Lowe, G. D. O.

    AU - Forbes, C. D.

    PY - 1984

    Y1 - 1984

    N2 - There is an increased frequency of arterial thrombosis in cigarette smokers. The changes in blood coagulation seen in these subjects have been studied by many workers but results have not always been in agreement. We wished to study the effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in ten habitual smokers, and to compare these results with non-smoking controls. Results show that the smoking group had higher plasma fibrinogen (p less than 0.04), lower plasminogen (p less than 0.02) and plasminogen activator (p less than 0.05), and higher plasma viscosity (p less than 0.003). The changes seen in cigarette smokers after smoking three cigarettes were an increase in the rate of platelet aggregation to ADP (p less than 0.02), an increase in alpha 2M, (p less than 0.02), and factor VIII RAG (p less than 0.05). Plasma viscosity was decreased (p less than 0.02) as was red cell deformability (p less than 0.02). We confirm an increased tendency to hypercoagulability in smokers compared to controls which becomes more pronounced immediately after smoking three cigarettes.

    AB - There is an increased frequency of arterial thrombosis in cigarette smokers. The changes in blood coagulation seen in these subjects have been studied by many workers but results have not always been in agreement. We wished to study the effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in ten habitual smokers, and to compare these results with non-smoking controls. Results show that the smoking group had higher plasma fibrinogen (p less than 0.04), lower plasminogen (p less than 0.02) and plasminogen activator (p less than 0.05), and higher plasma viscosity (p less than 0.003). The changes seen in cigarette smokers after smoking three cigarettes were an increase in the rate of platelet aggregation to ADP (p less than 0.02), an increase in alpha 2M, (p less than 0.02), and factor VIII RAG (p less than 0.05). Plasma viscosity was decreased (p less than 0.02) as was red cell deformability (p less than 0.02). We confirm an increased tendency to hypercoagulability in smokers compared to controls which becomes more pronounced immediately after smoking three cigarettes.

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    SN - 0340-6245

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