The effects of borage oil supplementation on non-steroidal anti-inflammatory drug requirements in patients with rheumatoid arthritis

Pradeep Kumar, Andrea Strang, Meilin Ho, Christine Maple, Daniel Radederstoff, Kenneth Morley, Jill Belch

Research output: Contribution to journalArticle

Abstract

Objective: Dietary supplementation with evening primrose oil and fish oils have been shown to be beneficial in rheumatoid arthritis (RA). We investigated whether dietary supplementation with borage(starflower) oil could be substituted for non-steroidal anti-inflammatory drugs (NSAIDs), without exacerbation/worsening of clinical measures of disease activity in patients with RA. Methods: 28 patients were enrolled in the study. 14 patients received GLA-containing oil and 14 placebo. Patients were reviewed at 4, 12, 24 and 36 weeks and asked to gradually reduce their NSAID dose only if this did not exacerbate RA symptoms. Disease activity was assessed clinically using the Ritchie articular index (RAI), grip strength, duration of morning stiffness, 10cm visual analogue pain scale and subjective response. Erythrocyte Sedimentation Rate (ESR) and C - reactive protein (CRP) were measured also. Results: Patient-centered outcomes were improved on active treatment, with a significant reduction in pain (p=0.0013, student's 2-tailed t-test), improvement in well being (Pearson Chi Square 6.8, p=0.032; likelihood-ratio Chi Square 7.2, p=0.027). There was a trend towards reduced NSAID requirement in the borage oil group (p=0.066, student's 2-tailed t-test). Conclusion: This study suggests that Borage oil does has a beneficial effect on controlling pain.
Original languageEnglish
JournalJournal of Complementary and Integrative Medicine
Volume5
Issue number1
DOIs
Publication statusPublished - 1 Jan 2008

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Rheumatoid Arthritis
Anti-Inflammatory Agents
Pharmaceutical Preparations
Dietary Supplements
Students
Pain
Fish Oils
Blood Sedimentation
Hand Strength
Pain Measurement
C-Reactive Protein
Oils
Joints
Placebos
borage oil
Therapeutics

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Kumar, Pradeep ; Strang, Andrea ; Ho, Meilin ; Maple, Christine ; Radederstoff, Daniel ; Morley, Kenneth ; Belch, Jill. / The effects of borage oil supplementation on non-steroidal anti-inflammatory drug requirements in patients with rheumatoid arthritis. In: Journal of Complementary and Integrative Medicine. 2008 ; Vol. 5, No. 1.
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abstract = "Objective: Dietary supplementation with evening primrose oil and fish oils have been shown to be beneficial in rheumatoid arthritis (RA). We investigated whether dietary supplementation with borage(starflower) oil could be substituted for non-steroidal anti-inflammatory drugs (NSAIDs), without exacerbation/worsening of clinical measures of disease activity in patients with RA. Methods: 28 patients were enrolled in the study. 14 patients received GLA-containing oil and 14 placebo. Patients were reviewed at 4, 12, 24 and 36 weeks and asked to gradually reduce their NSAID dose only if this did not exacerbate RA symptoms. Disease activity was assessed clinically using the Ritchie articular index (RAI), grip strength, duration of morning stiffness, 10cm visual analogue pain scale and subjective response. Erythrocyte Sedimentation Rate (ESR) and C - reactive protein (CRP) were measured also. Results: Patient-centered outcomes were improved on active treatment, with a significant reduction in pain (p=0.0013, student's 2-tailed t-test), improvement in well being (Pearson Chi Square 6.8, p=0.032; likelihood-ratio Chi Square 7.2, p=0.027). There was a trend towards reduced NSAID requirement in the borage oil group (p=0.066, student's 2-tailed t-test). Conclusion: This study suggests that Borage oil does has a beneficial effect on controlling pain.",
author = "Pradeep Kumar and Andrea Strang and Meilin Ho and Christine Maple and Daniel Radederstoff and Kenneth Morley and Jill Belch",
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The effects of borage oil supplementation on non-steroidal anti-inflammatory drug requirements in patients with rheumatoid arthritis. / Kumar, Pradeep; Strang, Andrea; Ho, Meilin; Maple, Christine; Radederstoff, Daniel; Morley, Kenneth; Belch, Jill.

In: Journal of Complementary and Integrative Medicine, Vol. 5, No. 1, 01.01.2008.

Research output: Contribution to journalArticle

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AU - Strang, Andrea

AU - Ho, Meilin

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AU - Morley, Kenneth

AU - Belch, Jill

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N2 - Objective: Dietary supplementation with evening primrose oil and fish oils have been shown to be beneficial in rheumatoid arthritis (RA). We investigated whether dietary supplementation with borage(starflower) oil could be substituted for non-steroidal anti-inflammatory drugs (NSAIDs), without exacerbation/worsening of clinical measures of disease activity in patients with RA. Methods: 28 patients were enrolled in the study. 14 patients received GLA-containing oil and 14 placebo. Patients were reviewed at 4, 12, 24 and 36 weeks and asked to gradually reduce their NSAID dose only if this did not exacerbate RA symptoms. Disease activity was assessed clinically using the Ritchie articular index (RAI), grip strength, duration of morning stiffness, 10cm visual analogue pain scale and subjective response. Erythrocyte Sedimentation Rate (ESR) and C - reactive protein (CRP) were measured also. Results: Patient-centered outcomes were improved on active treatment, with a significant reduction in pain (p=0.0013, student's 2-tailed t-test), improvement in well being (Pearson Chi Square 6.8, p=0.032; likelihood-ratio Chi Square 7.2, p=0.027). There was a trend towards reduced NSAID requirement in the borage oil group (p=0.066, student's 2-tailed t-test). Conclusion: This study suggests that Borage oil does has a beneficial effect on controlling pain.

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