The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects

Faisel Khan, Khaild Elherika, Caroline Bolton-Smith, Rebecca Barr, Alexander Hill, Inez Murrie, Jill J. F. Belch

    Research output: Contribution to journalArticle

    80 Citations (Scopus)

    Abstract

    OBJECTIVE: Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years. METHODS: In a double-blind, randomised, placebo controlled study, 173 healthy volunteers took one of six oil supplements for 8 months. Supplements were placebo, oleic acid rich sunflower oil, evening primrose oil, soya bean oil, tuna fish oil, and tuna/evening primrose oil mix. Endothelium-dependent and independent vascular responses were measured in the forearm skin using laser Doppler imaging following iontophoretic applications of acetylcholine and sodium nitroprusside, respectively. RESULTS: Acetylcholine, but not sodium nitroprusside responses were significantly improved after tuna oil supplementation (P=0.02). Additionally, there were significant positive correlations between acetylcholine responses and n-3 fatty acid levels in the plasma and erythrocyte membrane phospholipids after tuna oil supplementation. No significant changes in vascular response were seen after supplementation with any of the other oils. CONCLUSIONS: Fish oil supplementation has a beneficial effect on endothelial function, even in normal healthy subjects. Modification of the diet by an increase of 6% in eicosapentaenoic acid and 27% in docosahexaenoic acid (equivalent to eating oily fish 2-3 times/week) might have significant beneficial effects on cardiovascular function and health.
    Original languageEnglish
    Pages (from-to)955-962
    Number of pages8
    JournalCardiovascular Research
    Volume59
    Issue number4
    DOIs
    Publication statusPublished - Oct 2003

    Fingerprint

    Tuna
    Blood Vessels
    Healthy Volunteers
    Oils
    Fatty Acids
    Acetylcholine
    Fish Oils
    Nitroprusside
    Placebos
    Diet Therapy
    Soybean Oil
    Eicosapentaenoic Acid
    Docosahexaenoic Acids
    Omega-3 Fatty Acids
    Erythrocyte Membrane
    Oleic Acid
    Forearm
    Endothelium
    Phospholipids
    Fishes

    Keywords

    • Acetylcholine
    • Endothelial function
    • Microcirculation
    • Nitric oxide
    • Vasoconstriction/dilation

    Cite this

    Khan, Faisel ; Elherika, Khaild ; Bolton-Smith, Caroline ; Barr, Rebecca ; Hill, Alexander ; Murrie, Inez ; Belch, Jill J. F. / The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. In: Cardiovascular Research. 2003 ; Vol. 59, No. 4. pp. 955-962.
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    abstract = "OBJECTIVE: Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years. METHODS: In a double-blind, randomised, placebo controlled study, 173 healthy volunteers took one of six oil supplements for 8 months. Supplements were placebo, oleic acid rich sunflower oil, evening primrose oil, soya bean oil, tuna fish oil, and tuna/evening primrose oil mix. Endothelium-dependent and independent vascular responses were measured in the forearm skin using laser Doppler imaging following iontophoretic applications of acetylcholine and sodium nitroprusside, respectively. RESULTS: Acetylcholine, but not sodium nitroprusside responses were significantly improved after tuna oil supplementation (P=0.02). Additionally, there were significant positive correlations between acetylcholine responses and n-3 fatty acid levels in the plasma and erythrocyte membrane phospholipids after tuna oil supplementation. No significant changes in vascular response were seen after supplementation with any of the other oils. CONCLUSIONS: Fish oil supplementation has a beneficial effect on endothelial function, even in normal healthy subjects. Modification of the diet by an increase of 6{\%} in eicosapentaenoic acid and 27{\%} in docosahexaenoic acid (equivalent to eating oily fish 2-3 times/week) might have significant beneficial effects on cardiovascular function and health.",
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    author = "Faisel Khan and Khaild Elherika and Caroline Bolton-Smith and Rebecca Barr and Alexander Hill and Inez Murrie and Belch, {Jill J. F.}",
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    The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. / Khan, Faisel; Elherika, Khaild; Bolton-Smith, Caroline; Barr, Rebecca; Hill, Alexander; Murrie, Inez; Belch, Jill J. F.

    In: Cardiovascular Research, Vol. 59, No. 4, 10.2003, p. 955-962.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects

    AU - Khan, Faisel

    AU - Elherika, Khaild

    AU - Bolton-Smith, Caroline

    AU - Barr, Rebecca

    AU - Hill, Alexander

    AU - Murrie, Inez

    AU - Belch, Jill J. F.

    N1 - dc.publisher: Oxford University Press

    PY - 2003/10

    Y1 - 2003/10

    N2 - OBJECTIVE: Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years. METHODS: In a double-blind, randomised, placebo controlled study, 173 healthy volunteers took one of six oil supplements for 8 months. Supplements were placebo, oleic acid rich sunflower oil, evening primrose oil, soya bean oil, tuna fish oil, and tuna/evening primrose oil mix. Endothelium-dependent and independent vascular responses were measured in the forearm skin using laser Doppler imaging following iontophoretic applications of acetylcholine and sodium nitroprusside, respectively. RESULTS: Acetylcholine, but not sodium nitroprusside responses were significantly improved after tuna oil supplementation (P=0.02). Additionally, there were significant positive correlations between acetylcholine responses and n-3 fatty acid levels in the plasma and erythrocyte membrane phospholipids after tuna oil supplementation. No significant changes in vascular response were seen after supplementation with any of the other oils. CONCLUSIONS: Fish oil supplementation has a beneficial effect on endothelial function, even in normal healthy subjects. Modification of the diet by an increase of 6% in eicosapentaenoic acid and 27% in docosahexaenoic acid (equivalent to eating oily fish 2-3 times/week) might have significant beneficial effects on cardiovascular function and health.

    AB - OBJECTIVE: Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years. METHODS: In a double-blind, randomised, placebo controlled study, 173 healthy volunteers took one of six oil supplements for 8 months. Supplements were placebo, oleic acid rich sunflower oil, evening primrose oil, soya bean oil, tuna fish oil, and tuna/evening primrose oil mix. Endothelium-dependent and independent vascular responses were measured in the forearm skin using laser Doppler imaging following iontophoretic applications of acetylcholine and sodium nitroprusside, respectively. RESULTS: Acetylcholine, but not sodium nitroprusside responses were significantly improved after tuna oil supplementation (P=0.02). Additionally, there were significant positive correlations between acetylcholine responses and n-3 fatty acid levels in the plasma and erythrocyte membrane phospholipids after tuna oil supplementation. No significant changes in vascular response were seen after supplementation with any of the other oils. CONCLUSIONS: Fish oil supplementation has a beneficial effect on endothelial function, even in normal healthy subjects. Modification of the diet by an increase of 6% in eicosapentaenoic acid and 27% in docosahexaenoic acid (equivalent to eating oily fish 2-3 times/week) might have significant beneficial effects on cardiovascular function and health.

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    KW - Endothelial function

    KW - Microcirculation

    KW - Nitric oxide

    KW - Vasoconstriction/dilation

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    DO - 10.1016/S0008-6363(03)00395-X

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    EP - 962

    JO - Cardiovascular Research

    JF - Cardiovascular Research

    SN - 0008-6363

    IS - 4

    ER -