The effects of fibronectin on the adhesion and migration of chinese hamster ovary cells on collagen substrata

S L Schor, A M Schor, G W Bazill

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Data are presented indicating that the adhesion of Chinese hamster ovary cells (CHO) to films of denatured type I collagen occurs by a fibronectin-dependent mechanism, whereas the adhesion of these cells to 3-dimensional gels of native type I collagen fibres may occur by either a rapid, fibronectin-dependent mechanism or by a slower, fibronectin-independent mechanism, whereas the adhesion of these cells to 3-dimensional gels of native type I collagen fibres may occur by either a rapid, fibronectin-dependent mechanism or by a slower, fibronectin-independent mechanism. Data are also presented indicating that fibronectin promotes the migration of CHO cells on native type I collagen fibres.

    Original languageEnglish
    Pages (from-to)299-310
    Number of pages12
    JournalJournal of Cell Science
    Volume49
    Publication statusPublished - Jun 1981

    Keywords

    • Animals
    • Cell Adhesion/drug effects
    • Cell Division/drug effects
    • Cell Line
    • Cell Movement/drug effects
    • Collagen
    • Cricetinae
    • Cricetulus
    • Female
    • Fibronectins/pharmacology
    • Ovary/cytology

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