The effects of fibronectin on the migration of human foreskin fibroblasts and Syrian hamster melanoma cells into three-dimensional gels of native collagen fibres

S L Schor, A M Schor, G W Bazill

    Research output: Contribution to journalArticlepeer-review

    63 Citations (Scopus)

    Abstract

    The effects of fibronectin on the migration of human skin fibroblasts and Syrian hamster melanoma cells into 3-dimensional gels of native collagen fibres have been examined. Cell migration into the 3-dimensional gel was measured by plating cells on the gel surface and then determining the percentage of cells within the gel at various times thereafter by direct microscopic examination. We find that fibronectin bound to collagen inhibits the migration of human skin fibroblasts and stimulates the migration of melanoma cells into the gel matrix. Fibronectin had no apparent effect on cell adhesion to the collagen gels, proliferation or morphology under the conditions studied.

    Original languageEnglish
    Pages (from-to)301-14
    Number of pages14
    JournalJournal of Cell Science
    Volume48
    Publication statusPublished - Apr 1981

    Keywords

    • Animals
    • Cell Count
    • Cell Division/drug effects
    • Cell Movement/drug effects
    • Cells, Cultured
    • Collagen
    • Cricetinae
    • Fibroblasts/drug effects
    • Fibronectins/pharmacology
    • Humans
    • Melanoma/pathology
    • Mesocricetus
    • Neoplasms, Experimental/pathology
    • Skin/cytology

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