The effects of mutant Ras proteins on the cell signalome

Tamás Takács, Gyöngyi Kudlik, Anita Kurilla, Bálint Szeder, László Buday, Virag Vas (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)
2 Downloads (Pure)

Abstract

The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation. Ras is a key molecule that controls several tumorigenesis-related processes, and mutations in RAS genes often lead to unbiased intensification of signaling networks that fuel cancer progression. In this article, we review recent studies that describe mutant Ras-regulated signaling routes and their cross-talk. In addition to the two main Ras-driven signaling pathways, i.e., the RAF/MEK/ERK and PI3K/AKT/mTOR pathways, we have also collected emerging data showing the importance of Ras in other signaling pathways, including the RAC/PAK, RalGDS/Ral, and PKC/PLC signaling pathways. Moreover, microRNA-regulated Ras-associated signaling pathways are also discussed to highlight the importance of Ras regulation in cancer. Finally, emerging data show that the signal alterations in specific cell types, such as cancer stem cells, could promote cancer development. Therefore, we also cover the up-to-date findings related to Ras-regulated signal transduction in cancer stem cells.

Original languageEnglish
Pages (from-to)1051-1065
Number of pages15
JournalCancer and Metastasis Reviews
Volume39
Issue number4
Early online date9 Jul 2020
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Mutant Ras protein
  • Phosphorylation
  • Signal transduction
  • Tumorigenesis

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