The effects of PDT in primary malignant brain tumours could be improved by intraoperative radiotherapy

Matthew Lyons, Isaac Phang, Sam Eljamel

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Introduction: GBM has a poor survival despite surgery and chemoradiotherapy. Cytoreduction and PDT have postulated to afford better local GBM-control. However, the interaction of PDT with newer novel therapies had not been fully investigated. This study reviewed the impact of PDT in conjunction with intraoperative radiotherapy.

    Methods: Case note review of prospectively collected data of GBMs treated surgically by the senior author (SE). Patients received standard therapy (ST), ST + PDT or ST + PDT + IORT. ST involved maximum safe resection, PDT involved intracavity 100 J/cm(2) 630 nm laser and IORT involved intracavity 10-15 Gys using the PRS400 (R). Patients were followed up clinically and radiologically till death.

    Results: There were 73 patients included in this analysis (42 males). The average age was 59 years. Thirty received PDT and 43 did not. The mean survival of PDT-patients was significantly longer than those had ST alone (62.9 weeks vs. 20.6 weeks) (p=0.001). Patients <65 year of age survived longer than those >= 65 year (p=0.033). IORT on its own did not make a significant difference to survival (p=0.111). However the average survival for patients who received PDT + IORT was substantially higher than those who received PDT alone (79 weeks vs. 39.7 weeks). Using a Cox regression covariant analysis, demonstrated that PDT was the only therapy to make a statistically significant difference to survival (p=0.018).

    Conclusions: PDT in high grade glioma was statistically significant therapeutic modality and its effects were further improved by IORT. (c) 2011 Elsevier B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)40-45
    Number of pages6
    JournalPhotodiagnosis and photodynamic therapy
    Volume9
    Issue number1
    DOIs
    Publication statusPublished - Mar 2012

    Cite this

    @article{2c99d6c665d540c7b10a126732e0daaa,
    title = "The effects of PDT in primary malignant brain tumours could be improved by intraoperative radiotherapy",
    abstract = "Introduction: GBM has a poor survival despite surgery and chemoradiotherapy. Cytoreduction and PDT have postulated to afford better local GBM-control. However, the interaction of PDT with newer novel therapies had not been fully investigated. This study reviewed the impact of PDT in conjunction with intraoperative radiotherapy.Methods: Case note review of prospectively collected data of GBMs treated surgically by the senior author (SE). Patients received standard therapy (ST), ST + PDT or ST + PDT + IORT. ST involved maximum safe resection, PDT involved intracavity 100 J/cm(2) 630 nm laser and IORT involved intracavity 10-15 Gys using the PRS400 (R). Patients were followed up clinically and radiologically till death.Results: There were 73 patients included in this analysis (42 males). The average age was 59 years. Thirty received PDT and 43 did not. The mean survival of PDT-patients was significantly longer than those had ST alone (62.9 weeks vs. 20.6 weeks) (p=0.001). Patients <65 year of age survived longer than those >= 65 year (p=0.033). IORT on its own did not make a significant difference to survival (p=0.111). However the average survival for patients who received PDT + IORT was substantially higher than those who received PDT alone (79 weeks vs. 39.7 weeks). Using a Cox regression covariant analysis, demonstrated that PDT was the only therapy to make a statistically significant difference to survival (p=0.018).Conclusions: PDT in high grade glioma was statistically significant therapeutic modality and its effects were further improved by IORT. (c) 2011 Elsevier B.V. All rights reserved.",
    author = "Matthew Lyons and Isaac Phang and Sam Eljamel",
    year = "2012",
    month = "3",
    doi = "10.1016/j.pdpdt.2011.12.001",
    language = "English",
    volume = "9",
    pages = "40--45",
    journal = "Photodiagnosis and Photodynamic Therapy",
    issn = "1572-1000",
    publisher = "Elsevier",
    number = "1",

    }

    The effects of PDT in primary malignant brain tumours could be improved by intraoperative radiotherapy. / Lyons, Matthew; Phang, Isaac; Eljamel, Sam.

    In: Photodiagnosis and photodynamic therapy, Vol. 9, No. 1, 03.2012, p. 40-45.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The effects of PDT in primary malignant brain tumours could be improved by intraoperative radiotherapy

    AU - Lyons, Matthew

    AU - Phang, Isaac

    AU - Eljamel, Sam

    PY - 2012/3

    Y1 - 2012/3

    N2 - Introduction: GBM has a poor survival despite surgery and chemoradiotherapy. Cytoreduction and PDT have postulated to afford better local GBM-control. However, the interaction of PDT with newer novel therapies had not been fully investigated. This study reviewed the impact of PDT in conjunction with intraoperative radiotherapy.Methods: Case note review of prospectively collected data of GBMs treated surgically by the senior author (SE). Patients received standard therapy (ST), ST + PDT or ST + PDT + IORT. ST involved maximum safe resection, PDT involved intracavity 100 J/cm(2) 630 nm laser and IORT involved intracavity 10-15 Gys using the PRS400 (R). Patients were followed up clinically and radiologically till death.Results: There were 73 patients included in this analysis (42 males). The average age was 59 years. Thirty received PDT and 43 did not. The mean survival of PDT-patients was significantly longer than those had ST alone (62.9 weeks vs. 20.6 weeks) (p=0.001). Patients <65 year of age survived longer than those >= 65 year (p=0.033). IORT on its own did not make a significant difference to survival (p=0.111). However the average survival for patients who received PDT + IORT was substantially higher than those who received PDT alone (79 weeks vs. 39.7 weeks). Using a Cox regression covariant analysis, demonstrated that PDT was the only therapy to make a statistically significant difference to survival (p=0.018).Conclusions: PDT in high grade glioma was statistically significant therapeutic modality and its effects were further improved by IORT. (c) 2011 Elsevier B.V. All rights reserved.

    AB - Introduction: GBM has a poor survival despite surgery and chemoradiotherapy. Cytoreduction and PDT have postulated to afford better local GBM-control. However, the interaction of PDT with newer novel therapies had not been fully investigated. This study reviewed the impact of PDT in conjunction with intraoperative radiotherapy.Methods: Case note review of prospectively collected data of GBMs treated surgically by the senior author (SE). Patients received standard therapy (ST), ST + PDT or ST + PDT + IORT. ST involved maximum safe resection, PDT involved intracavity 100 J/cm(2) 630 nm laser and IORT involved intracavity 10-15 Gys using the PRS400 (R). Patients were followed up clinically and radiologically till death.Results: There were 73 patients included in this analysis (42 males). The average age was 59 years. Thirty received PDT and 43 did not. The mean survival of PDT-patients was significantly longer than those had ST alone (62.9 weeks vs. 20.6 weeks) (p=0.001). Patients <65 year of age survived longer than those >= 65 year (p=0.033). IORT on its own did not make a significant difference to survival (p=0.111). However the average survival for patients who received PDT + IORT was substantially higher than those who received PDT alone (79 weeks vs. 39.7 weeks). Using a Cox regression covariant analysis, demonstrated that PDT was the only therapy to make a statistically significant difference to survival (p=0.018).Conclusions: PDT in high grade glioma was statistically significant therapeutic modality and its effects were further improved by IORT. (c) 2011 Elsevier B.V. All rights reserved.

    U2 - 10.1016/j.pdpdt.2011.12.001

    DO - 10.1016/j.pdpdt.2011.12.001

    M3 - Article

    VL - 9

    SP - 40

    EP - 45

    JO - Photodiagnosis and Photodynamic Therapy

    JF - Photodiagnosis and Photodynamic Therapy

    SN - 1572-1000

    IS - 1

    ER -