The effects of potassium channel openers on isolated pregnant human myometrium before and after the onset of labor: potential for tocolysis

John J. Morrison, Michael L. J. Ashford, Raheela N. Khan, Stephen K. Smith

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    61 Citations (Scopus)

    Abstract

    Objective: Our purpose was to investigate the effects and pharmacologic properties of potassium channel openers in isolated pregnant human myometrium.
    Study Design: Biopsy specimens of myometrium obtained from 67 women during pregnancy and labor were used for isometric recording under physiologic conditions.
    Results: Levcromakalim and pinacidil, two prototype potassium channel openers, are potent inhibitors of spontaneous and induced (0.5 nmol/L oxytocin and 10 µmol/L phenylephrine) contractions in isolated human pregnant myometrium, obtained before and after the onset of labor. The sulfonylurea glibenclamide is an apparent competitive antagonist of this inhibition. No antagonism was observed with the sulfonylurea tolbutamide. Both potassium channel openers significantly inhibited contractility evoked by low (10 and 20 mmol/L) but not high (40 and 80 mmol/L) concentrations of extracellular potassium chloride.
    Conclusion: These findings sugggest that the relaxant ability of levcromakalim and pinacidil in human pregnant myometrium is because of potassium channel activation. This introduces a potential new approach for tocolysis.
    Original languageEnglish
    Pages (from-to)1277-1285
    Number of pages9
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume169
    Issue number5
    DOIs
    Publication statusPublished - Nov 1993

    Keywords

    • Pinacidil
    • Benzopyrans
    • Sulfonylurea Compounds
    • Humans
    • Cromakalim
    • Guanidines
    • Labor Onset
    • Pyrroles
    • Potassium Channels
    • Oxytocin
    • Potassium Chloride
    • Pregnancy
    • Tocolytic Agents
    • Phenylephrine
    • Uterine Contraction
    • Myometrium
    • Female

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