Event-related potentials (ERPs) were recorded during a task requiring continuous recognition memory for visually-presented words. Twelve subjects each performed the task twice, once following the administration of scopolamine, and once after receiving a saline placebo). In the placebo condition, correctly detected "old" words (i.e., words that had been presented once before during the task) evoked more positive- going ERPs than did "new" words. Scopolamine caused a substantial impairment in task performance. but did not reduce the size of these old-word/new-word ERP differences. It is concluded that old/new ERP effects are unlikely to reflect cholinergically-mediated neural activity underlying normal recognition memory.
|Number of pages||9|
|Publication status||Published - 1992|
- Acetylcholine; brain potentials; hyoscine; memory; recognition; scopolamine Brain potentials; words; dementia; systems; p300; dissociation; amnesia; lesions