The effects of Scopolamine on event-related potentials in a continuous recognition memory task

Douglas D. Potter, Charles D. Pickles, Richard C. Roberts, Michael D. Rugg

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    38 Citations (Scopus)

    Abstract

    Event-related potentials (ERPs) were recorded during a task requiring continuous recognition memory for visually-presented words. Twelve subjects each performed the task twice, once following the administration of scopolamine, and once after receiving a saline placebo). In the placebo condition, correctly detected "old" words (i.e., words that had been presented once before during the task) evoked more positive- going ERPs than did "new" words. Scopolamine caused a substantial impairment in task performance. but did not reduce the size of these old-word/new-word ERP differences. It is concluded that old/new ERP effects are unlikely to reflect cholinergically-mediated neural activity underlying normal recognition memory.
    Original languageEnglish
    Pages (from-to)29-37
    Number of pages9
    JournalPsychophysiology
    Volume29
    Issue number1
    DOIs
    Publication statusPublished - 1992

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    Keywords

    • Acetylcholine; brain potentials; hyoscine; memory; recognition; scopolamine Brain potentials; words; dementia; systems; p300; dissociation; amnesia; lesions

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