The endocannabinoid system: no longer anonymous in the control of nitrergic signalling?

Christopher Lipina, Harinder S. Hundal (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
187 Downloads (Pure)

Abstract

The endocannabinoid system (ECS) is a key cellular signalling system which has been implicated in the regulation of diverse cellular functions. Importantly, growing evidence suggests that the biological actions of the ECS may, in part, be mediated through its ability to regulate the production and/or release of nitric oxide, a ubiquitous bioactive molecule which functions as a versatile signalling intermediate. Herein, we review and discuss evidence pertaining to ECS mediated regulation of nitric oxide production, the involvement of reactive nitrogen species in regulating ECS induced signal transduction, as well as highlighting emerging work supporting nitrergic modulation of ECS function. Importantly, the studies outlined reveal that interactions between the ECS and nitrergic signalling systems can be both stimulatory and inhibitory in nature, depending on cellular context. Moreover, such crosstalk may act to maintain proper cell function, whereas abnormalities in either system can undermine cellular homeostasis and contribute to various pathologies associated with their dysregulation. Consequently, future studies targeting these signalling systems may provide new insights into the potential role of the ECS - nitric oxide signalling axis in disease development, and/or lead to the identification of novel therapeutic targets for the treatment of nitrosative stress-related neurological, cardiovascular and metabolic disorders.
Original languageEnglish
Pages (from-to)91-103
Number of pages13
JournalJournal of Molecular Cell Biology
Volume9
Issue number2
DOIs
Publication statusPublished - 27 Jan 2017

Keywords

  • Endocannabinoid System
  • Reactive Nitrogen Species
  • Nitric Oxide
  • Nitrosative Stress
  • Cannabinoid Receptor

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