The European Biological Variation Study (EuBIVAS): Biological variation data for testosterone, follicle stimulating hormone, prolactin, luteinizing hormone and dehydroepiandrosterone sulfate in men

Outi Itkonen (Lead / Corresponding author), Niels Jonker, Aasne K Aarsand, Sverre Sandberg, Jorge Diaz-Garzon, Pilar Fernandez-Calle, Abdurrahman Coskun, William A. Bartlett, Massimo Locatelli, Anna Carobene

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Abstract

BACKGROUND: Knowledge of biological variation (BV) of hormones is essential for interpretation of laboratory tests and for diagnostics of endocrinological and reproductive diseases. There is a lack of robust BV data for many hormones in men.

METHODS: We used serum samples collected weekly over 10 weeks from the European Biological Variation Study (EuBIVAS) to determine BV of testosterone, follicle-stimulating hormone (FSH), prolactin, luteinizing hormone (LH) and dehydroepiandrosterone sulfate (DHEA-S) in 38 men. We derived within-subject (CVI) and between-subject (CVG) BV estimates by CV-ANOVA after trend, outlier, and homogeneity analysis and calculated reference change values, index of individuality (II), and analytical performance specifications.

RESULTS: The CVI estimates were 10 % for testosterone, 8 % for FSH, 13 % for prolactin, 22 % for LH, and 9 % for DHEA-S, respectively. The IIs ranged between 0.14 for FSH to 0.66 for LH, indicating high individuality.

CONCLUSIONS: In this study, we have used samples from the highly powered EuBIVAS study to derive BV estimates for testosterone, FSH, prolactin, LH and DHEA-S in men. Our data confirm previously published BV estimates of testosterone, FSH and LH. For prolactin and DHEA-S BV data for men are reported for the first time.

Original languageEnglish
Article number117806
Number of pages7
JournalClinica Chimica Acta
Volume555
Early online date9 Feb 2024
DOIs
Publication statusPublished - 1 Mar 2024

Keywords

  • Biological variation
  • Clinical interpretation
  • EuBIVAS
  • Hormones
  • Laboratory medicine
  • Reference change value

ASJC Scopus subject areas

  • Biochemistry, medical
  • Biochemistry
  • Clinical Biochemistry

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