The evolution of aggregative multicellularity and cell-cell communication in the Dictyostelia

Qingyou Du, Yoshinori Kawabe, Christina Schilde, Zhi-hui Chen, Pauline Schaap (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    70 Citations (Scopus)
    170 Downloads (Pure)


    Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review, we summarise trends in the evolution of cell-type specialisation and behavioural complexity in the four major groups of Dictyostelia. We describe the cell-cell communication systems that control the developmental programme of D. discoideum, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation. Comparative genomic studies showed that the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellular amoebozoan ancestors. Comparative functional analysis revealed that cAMP signalling in D. discoideum originated from a second messenger role in amoebozoan encystation. We highlight some molecular changes in cAMP signalling genes that were responsible for the novel roles of cAMP in multicellular development.

    Original languageEnglish
    Pages (from-to)3722-3733
    Number of pages12
    JournalJournal of Molecular Biology
    Issue number23
    Early online date15 Aug 2015
    Publication statusPublished - 20 Nov 2015


    • Cyclic nucleotide
    • Dual component signalling
    • Encystation
    • Evolution of multicellularity
    • Sporulation

    ASJC Scopus subject areas

    • Molecular Biology


    Dive into the research topics of 'The evolution of aggregative multicellularity and cell-cell communication in the Dictyostelia'. Together they form a unique fingerprint.

    Cite this