Projects per year
Abstract
Eukaryotic cells possess a remarkably diverse range of organelles that provide compartmentalization for distinct cellular functions and are likely responsible for the remarkable success of these organisms. The origins and subsequent elaboration of these compartments represent a key aspect in the transition between prokaryotic and eukaryotic cellular forms. The protein machinery required to build, maintain, and define many membranebound compartments is encoded by several paralog families, including small GTPases, coiled-bundle proteins, and proteins with β-propeller and α-solenoid secondary structures. Together these proteins provide the membrane coats and control systems to structure and coordinate the endomembrane system. Mechanistically and evolutionarily, they unite not only secretory or endocytic organelles but also the flagellum and nucleus. The ancient origins for these families have been revealed by recent findings, providing new perspectives on the deep evolutionary processes and relationships that underlie eukaryotic cell structure. Expected final online publication date for the Annual Review of Biochemistry Volume 86 is June 20, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Original language | English |
---|---|
Pages (from-to) | 637-657 |
Number of pages | 21 |
Journal | Annual Review of Biochemistry |
Volume | 86 |
Early online date | 3 May 2017 |
DOIs | |
Publication status | Published - Jun 2017 |
Keywords
- Journal article
- Membrane trafficking
- Nucleocytoplasmic transport
- Nuclear pore complex
- Coated vesicle
- Coatomer
- Clathrin
- Intraflagellar transport,
- Molecular evolution
- Protocoatomer
- Eukaryogenesis
Fingerprint
Dive into the research topics of 'The Evolution of Organellar Coat Complexes and Organization of the Eukaryotic Cell'. Together they form a unique fingerprint.Projects
- 2 Finished
-
Global Mechanisms for Control of the Trypanosome Proteome: Defining the Composition, Origins and Roles of Cullin E3 Ligases
Field, M. (Investigator)
1/01/17 → 31/12/19
Project: Research
-
Control of Gene Expression in Trypanosoes: Defining the Nuclear Lamina
Field, M. (Investigator)
1/07/16 → 29/02/20
Project: Research