The expression of 3-fucosylated-N-acetyl lactosamine carbohydrate determinants in renal tumours

S. Fleming, G. Brown

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    The distribution in renal tumours of 3-fucosyl-N-acetyl lactosamine has been studied by using the monoclonal antibodies AGF 4.36 and AGF 4.48 and immunoperoxidase methods on tissue sections. Seven of 19 nephroblastomas and 12 of 30 renal cell carcinomas contained the epitope. In nephroblastomas the epitope was found on the terminals of type B tubules in six cases and in one case on the type A or neoplastic tubules. In renal carcinoma the antigen was found on the surface of tumour cells. The results suggest that in kidneys bearing nephroblastomas ureteric bud elements may grow into the tumour from the adjacent kidney.
    Original languageEnglish
    Pages (from-to)171-182
    Number of pages12
    JournalHistopathology
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - 1987

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