The extracellular matrix and insulin resistance

Ashley S. Williams; Li Kang; David H. Wasserman

doi:10.1016/j.tem.2015.05.006

The extracellular matrix and insulin resistance

Ashley S. Williams, Li Kang, David H. Wasserman

Research output: Contribution to journal › Review article › peer-review

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Abstract

The extracellular matrix (ECM) is a highly-dynamic compartment that undergoes remodeling as a result of injury and repair. Over the past decade, mounting evidence in humans and rodents suggests that ECM remodeling is associated with diet-induced insulin resistance in several metabolic tissues. In addition, integrin receptors for the ECM have also been implicated in the regulation of insulin action. This review addresses what is currently known about the ECM, integrins, and insulin action in the muscle, liver, and adipose tissue. Understanding how ECM remodeling and integrin signaling regulate insulin action may aid in the development of new therapeutic targets for the treatment of insulin resistance and type 2 diabetes (T2D).

Original language	English
Pages (from-to)	357-366
Number of pages	10
Journal	Trends in Endocrinology and Metabolism
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.tem.2015.05.006
Publication status	Published - Jul 2015

Keywords

Extracellular matrix
Integrins
glucose homeostasis
Insulin Resistance
Liver
Muscle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2015.05.006

TEM-D-15-000548-1
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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AB - The extracellular matrix (ECM) is a highly-dynamic compartment that undergoes remodeling as a result of injury and repair. Over the past decade, mounting evidence in humans and rodents suggests that ECM remodeling is associated with diet-induced insulin resistance in several metabolic tissues. In addition, integrin receptors for the ECM have also been implicated in the regulation of insulin action. This review addresses what is currently known about the ECM, integrins, and insulin action in the muscle, liver, and adipose tissue. Understanding how ECM remodeling and integrin signaling regulate insulin action may aid in the development of new therapeutic targets for the treatment of insulin resistance and type 2 diabetes (T2D).

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KW - glucose homeostasis

KW - Insulin Resistance

KW - Liver

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JO - Trends in Endocrinology and Metabolism

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The extracellular matrix and insulin resistance

Abstract

Keywords

UN SDGs

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