The extracellular matrix and insulin resistance

Ashley S. Williams, Li Kang, David H. Wasserman

    Research output: Contribution to journalReview articlepeer-review

    153 Citations (Scopus)
    219 Downloads (Pure)


    The extracellular matrix (ECM) is a highly-dynamic compartment that undergoes remodeling as a result of injury and repair. Over the past decade, mounting evidence in humans and rodents suggests that ECM remodeling is associated with diet-induced insulin resistance in several metabolic tissues. In addition, integrin receptors for the ECM have also been implicated in the regulation of insulin action. This review addresses what is currently known about the ECM, integrins, and insulin action in the muscle, liver, and adipose tissue. Understanding how ECM remodeling and integrin signaling regulate insulin action may aid in the development of new therapeutic targets for the treatment of insulin resistance and type 2 diabetes (T2D).

    Original languageEnglish
    Pages (from-to)357-366
    Number of pages10
    JournalTrends in Endocrinology and Metabolism
    Issue number7
    Publication statusPublished - Jul 2015


    • Extracellular matrix
    • Integrins
    • glucose homeostasis
    • Insulin Resistance
    • Liver
    • Muscle


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