Abstract
The extracellular matrix (ECM) is a highly-dynamic compartment that undergoes remodeling as a result of injury and repair. Over the past decade, mounting evidence in humans and rodents suggests that ECM remodeling is associated with diet-induced insulin resistance in several metabolic tissues. In addition, integrin receptors for the ECM have also been implicated in the regulation of insulin action. This review addresses what is currently known about the ECM, integrins, and insulin action in the muscle, liver, and adipose tissue. Understanding how ECM remodeling and integrin signaling regulate insulin action may aid in the development of new therapeutic targets for the treatment of insulin resistance and type 2 diabetes (T2D).
| Original language | English |
|---|---|
| Pages (from-to) | 357-366 |
| Number of pages | 10 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 26 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2015 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Extracellular matrix
- Integrins
- glucose homeostasis
- Insulin Resistance
- Liver
- Muscle
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