The eye lens cytoskeleton

R. A. Quinlan, A. Sandilands, J. E. Procter, A. R. Prescott, A. M. Hutcheson, R. Dahm, C. Gribbon, P. Wallace, J. M. Carter

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    During lens cell differentiation there are a number of very characteristic morphological changes that occur. These include a 50- to 100-fold increase in cell length as the equatorial lens epithelial cells differentiate into fibre cells and the loss of the cellular organelles such as mitochondria, nuclei, Golgi apparatus and endoplasmic reticulum. Coincident with these changes are dramatic alterations in the organisation of the lens fibre cell cytoskeleton and in particular the lens-specific intermediate filament network comprising CP49 and filensin. Cell shape and cell polarisation as well as tissue integrity are all processes that depend upon the cytoskeleton and are therefore important to the lens. The unique aspects of the lenticular cytoskeleton are the subject of this review.

    Original languageEnglish
    Pages (from-to)409-416
    Number of pages8
    JournalEye (Basingstoke)
    Volume13
    Issue number3
    DOIs
    Publication statusPublished - May 1999

    Fingerprint

    Crystalline Lens
    Cytoskeleton
    Lenses
    Intermediate Filaments
    Cell Shape
    Golgi Apparatus
    Endoplasmic Reticulum
    Organelles
    Cell Differentiation
    Mitochondria
    Epithelial Cells

    Keywords

    • CP49
    • Cytoskeleton
    • Differentiation
    • Filensin
    • Intermediate filaments
    • Lens

    Cite this

    Quinlan, R. A., Sandilands, A., Procter, J. E., Prescott, A. R., Hutcheson, A. M., Dahm, R., ... Carter, J. M. (1999). The eye lens cytoskeleton. Eye (Basingstoke), 13(3), 409-416. https://doi.org/10.1038/eye.1999.115
    Quinlan, R. A. ; Sandilands, A. ; Procter, J. E. ; Prescott, A. R. ; Hutcheson, A. M. ; Dahm, R. ; Gribbon, C. ; Wallace, P. ; Carter, J. M. / The eye lens cytoskeleton. In: Eye (Basingstoke). 1999 ; Vol. 13, No. 3. pp. 409-416.
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    Quinlan, RA, Sandilands, A, Procter, JE, Prescott, AR, Hutcheson, AM, Dahm, R, Gribbon, C, Wallace, P & Carter, JM 1999, 'The eye lens cytoskeleton', Eye (Basingstoke), vol. 13, no. 3, pp. 409-416. https://doi.org/10.1038/eye.1999.115

    The eye lens cytoskeleton. / Quinlan, R. A.; Sandilands, A.; Procter, J. E.; Prescott, A. R.; Hutcheson, A. M.; Dahm, R.; Gribbon, C.; Wallace, P.; Carter, J. M.

    In: Eye (Basingstoke), Vol. 13, No. 3, 05.1999, p. 409-416.

    Research output: Contribution to journalArticle

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    AU - Quinlan, R. A.

    AU - Sandilands, A.

    AU - Procter, J. E.

    AU - Prescott, A. R.

    AU - Hutcheson, A. M.

    AU - Dahm, R.

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    AU - Wallace, P.

    AU - Carter, J. M.

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