The eye lens cytoskeleton

R. A. Quinlan; A. Sandilands; J. E. Procter; A. R. Prescott; A. M. Hutcheson; R. Dahm; C. Gribbon; P. Wallace; J. M. Carter

doi:10.1038/eye.1999.115

The eye lens cytoskeleton

R. A. Quinlan, A. Sandilands, J. E. Procter, A. R. Prescott, A. M. Hutcheson, R. Dahm, C. Gribbon, P. Wallace, J. M. Carter

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

During lens cell differentiation there are a number of very characteristic morphological changes that occur. These include a 50- to 100-fold increase in cell length as the equatorial lens epithelial cells differentiate into fibre cells and the loss of the cellular organelles such as mitochondria, nuclei, Golgi apparatus and endoplasmic reticulum. Coincident with these changes are dramatic alterations in the organisation of the lens fibre cell cytoskeleton and in particular the lens-specific intermediate filament network comprising CP49 and filensin. Cell shape and cell polarisation as well as tissue integrity are all processes that depend upon the cytoskeleton and are therefore important to the lens. The unique aspects of the lenticular cytoskeleton are the subject of this review.

Original language	English
Pages (from-to)	409-416
Number of pages	8
Journal	Eye (Basingstoke)
Volume	13
Issue number	3
DOIs	https://doi.org/10.1038/eye.1999.115
Publication status	Published - May 1999

Keywords

CP49
Cytoskeleton
Differentiation
Filensin
Intermediate filaments
Lens

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

Access to Document

10.1038/eye.1999.115

Cite this

@article{9c0fe6b9e9f84768a4a8b4bd04182778,

title = "The eye lens cytoskeleton",

abstract = "During lens cell differentiation there are a number of very characteristic morphological changes that occur. These include a 50- to 100-fold increase in cell length as the equatorial lens epithelial cells differentiate into fibre cells and the loss of the cellular organelles such as mitochondria, nuclei, Golgi apparatus and endoplasmic reticulum. Coincident with these changes are dramatic alterations in the organisation of the lens fibre cell cytoskeleton and in particular the lens-specific intermediate filament network comprising CP49 and filensin. Cell shape and cell polarisation as well as tissue integrity are all processes that depend upon the cytoskeleton and are therefore important to the lens. The unique aspects of the lenticular cytoskeleton are the subject of this review.",

keywords = "CP49, Cytoskeleton, Differentiation, Filensin, Intermediate filaments, Lens",

author = "Quinlan, {R. A.} and A. Sandilands and Procter, {J. E.} and Prescott, {A. R.} and Hutcheson, {A. M.} and R. Dahm and C. Gribbon and P. Wallace and Carter, {J. M.}",

year = "1999",

month = may,

doi = "10.1038/eye.1999.115",

language = "English",

volume = "13",

pages = "409--416",

journal = "Eye (Basingstoke)",

issn = "0950-222X",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - The eye lens cytoskeleton

AU - Quinlan, R. A.

AU - Sandilands, A.

AU - Procter, J. E.

AU - Prescott, A. R.

AU - Hutcheson, A. M.

AU - Dahm, R.

AU - Gribbon, C.

AU - Wallace, P.

AU - Carter, J. M.

PY - 1999/5

Y1 - 1999/5

N2 - During lens cell differentiation there are a number of very characteristic morphological changes that occur. These include a 50- to 100-fold increase in cell length as the equatorial lens epithelial cells differentiate into fibre cells and the loss of the cellular organelles such as mitochondria, nuclei, Golgi apparatus and endoplasmic reticulum. Coincident with these changes are dramatic alterations in the organisation of the lens fibre cell cytoskeleton and in particular the lens-specific intermediate filament network comprising CP49 and filensin. Cell shape and cell polarisation as well as tissue integrity are all processes that depend upon the cytoskeleton and are therefore important to the lens. The unique aspects of the lenticular cytoskeleton are the subject of this review.

AB - During lens cell differentiation there are a number of very characteristic morphological changes that occur. These include a 50- to 100-fold increase in cell length as the equatorial lens epithelial cells differentiate into fibre cells and the loss of the cellular organelles such as mitochondria, nuclei, Golgi apparatus and endoplasmic reticulum. Coincident with these changes are dramatic alterations in the organisation of the lens fibre cell cytoskeleton and in particular the lens-specific intermediate filament network comprising CP49 and filensin. Cell shape and cell polarisation as well as tissue integrity are all processes that depend upon the cytoskeleton and are therefore important to the lens. The unique aspects of the lenticular cytoskeleton are the subject of this review.

KW - CP49

KW - Cytoskeleton

KW - Differentiation

KW - Filensin

KW - Intermediate filaments

KW - Lens

UR - http://www.scopus.com/inward/record.url?scp=0032812753&partnerID=8YFLogxK

U2 - 10.1038/eye.1999.115

DO - 10.1038/eye.1999.115

M3 - Article

C2 - 10627818

AN - SCOPUS:0032812753

SN - 0950-222X

VL - 13

SP - 409

EP - 416

JO - Eye (Basingstoke)

JF - Eye (Basingstoke)

IS - 3

ER -

The eye lens cytoskeleton

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this