The first direct preparation of chiral functionalised ketones and their synthetic uses

José Barluenga; Beatriz Baragaña; Alejandro Alonso; José M. Concellón

doi:10.1039/C39940000969

The first direct preparation of chiral functionalised ketones and their synthetic uses

José Barluenga, Beatriz Baragaña, Alejandro Alonso, José M. Concellón

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Almost enantiomerically pure halogenated α-hydroxy and α-amino ketones can be prepared from O-protected lactates and tribenzylated alanine, respectively; whilst amino ketones 3g have also been transformed into the amino epoxide 7 with high diastereoselectivity.

Original language	English
Pages (from-to)	969-970
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	8
DOIs	https://doi.org/10.1039/C39940000969
Publication status	Published - 1994

ASJC Scopus subject areas

Molecular Medicine

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title = "The first direct preparation of chiral functionalised ketones and their synthetic uses",

abstract = "Almost enantiomerically pure halogenated α-hydroxy and α-amino ketones can be prepared from O-protected lactates and tribenzylated alanine, respectively; whilst amino ketones 3g have also been transformed into the amino epoxide 7 with high diastereoselectivity.",

author = "Jos{\'e} Barluenga and Beatriz Baraga{\~n}a and Alejandro Alonso and Concell{\'o}n, {Jos{\'e} M.}",

year = "1994",

doi = "10.1039/C39940000969",

language = "English",

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journal = "Journal of the Chemical Society, Chemical Communications",

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T1 - The first direct preparation of chiral functionalised ketones and their synthetic uses

AU - Barluenga, José

AU - Baragaña, Beatriz

AU - Alonso, Alejandro

AU - Concellón, José M.

PY - 1994

Y1 - 1994

N2 - Almost enantiomerically pure halogenated α-hydroxy and α-amino ketones can be prepared from O-protected lactates and tribenzylated alanine, respectively; whilst amino ketones 3g have also been transformed into the amino epoxide 7 with high diastereoselectivity.

AB - Almost enantiomerically pure halogenated α-hydroxy and α-amino ketones can be prepared from O-protected lactates and tribenzylated alanine, respectively; whilst amino ketones 3g have also been transformed into the amino epoxide 7 with high diastereoselectivity.

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U2 - 10.1039/C39940000969

DO - 10.1039/C39940000969

M3 - Article

AN - SCOPUS:37049068037

SN - 0022-4936

SP - 969

EP - 970

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 8

ER -

The first direct preparation of chiral functionalised ketones and their synthetic uses

Abstract

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