The future of reproductive cellular engineering in male infertility

Christopher J De Jonge; Christopher L R Barratt

doi:10.1016/S0094-0143(02)00077-0

The future of reproductive cellular engineering in male infertility

Christopher J De Jonge (Lead / Corresponding author), Christopher L R Barratt

Undergraduate Medicine

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Understanding of the pathophysiology of defective spermatogenesis, spermatozoa, and germ cell function must be advanced so that appropriate rational treatment, such as gene therapy, can be developed. Despite the dramatic advances in ART, one ultimate goal must be to develop treatment so that the couple can conceive naturally. Because such treatment will not be possible in all cases, a complementary step will be the ability to induce the production of haploid, functionally competent germ cells that can be used for ART. The achievement of these goals will be based on advances in many other disciplines. Whatever the future holds, it promises to be exciting.

Original language	English
Pages (from-to)	809-15
Number of pages	7
Journal	Urologic Clinics of North America
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/S0094-0143(02)00077-0
Publication status	Published - Nov 2002

Keywords

Biomedical Engineering/trends
Humans
Infertility, Male/genetics
Male
Reproductive Medicine/trends
Time Factors

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title = "The future of reproductive cellular engineering in male infertility",

abstract = "Understanding of the pathophysiology of defective spermatogenesis, spermatozoa, and germ cell function must be advanced so that appropriate rational treatment, such as gene therapy, can be developed. Despite the dramatic advances in ART, one ultimate goal must be to develop treatment so that the couple can conceive naturally. Because such treatment will not be possible in all cases, a complementary step will be the ability to induce the production of haploid, functionally competent germ cells that can be used for ART. The achievement of these goals will be based on advances in many other disciplines. Whatever the future holds, it promises to be exciting.",

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AU - De Jonge, Christopher J

AU - Barratt, Christopher L R

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N2 - Understanding of the pathophysiology of defective spermatogenesis, spermatozoa, and germ cell function must be advanced so that appropriate rational treatment, such as gene therapy, can be developed. Despite the dramatic advances in ART, one ultimate goal must be to develop treatment so that the couple can conceive naturally. Because such treatment will not be possible in all cases, a complementary step will be the ability to induce the production of haploid, functionally competent germ cells that can be used for ART. The achievement of these goals will be based on advances in many other disciplines. Whatever the future holds, it promises to be exciting.

AB - Understanding of the pathophysiology of defective spermatogenesis, spermatozoa, and germ cell function must be advanced so that appropriate rational treatment, such as gene therapy, can be developed. Despite the dramatic advances in ART, one ultimate goal must be to develop treatment so that the couple can conceive naturally. Because such treatment will not be possible in all cases, a complementary step will be the ability to induce the production of haploid, functionally competent germ cells that can be used for ART. The achievement of these goals will be based on advances in many other disciplines. Whatever the future holds, it promises to be exciting.

KW - Biomedical Engineering/trends

KW - Humans

KW - Infertility, Male/genetics

KW - Male

KW - Reproductive Medicine/trends

KW - Time Factors

U2 - 10.1016/S0094-0143(02)00077-0

DO - 10.1016/S0094-0143(02)00077-0

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EP - 815

JO - Urologic Clinics of North America

JF - Urologic Clinics of North America

IS - 4

ER -

The future of reproductive cellular engineering in male infertility

Abstract

Keywords

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