The GABAA receptor: An important target for the general anaesthetic etomidate

J. J. Lambert (Lead / Corresponding author), A. R. Haythornthwaite, D. R. Peden, M. B. Herd, K. A. Wafford, T. W. Rosahl, D. Belelli

    Research output: Contribution to journalArticlepeer-review


    The general anaesthetic etomidate potently and selectively enhances the function of the GABAA receptor. Furthermore, etomidate is selective for GABAA receptors that incorporate a β2 or a β3 subunit, but is relatively ineffective at equivalent receptors containing the β1 subunit. This selectivity is governed by the nature of a single amino acid residue (asparagine, N for β2 and β3; serine, S for β1). Utilising this knowledge gene targeting was used to create a mouse in which the β2 subunit was engineered to be relatively insensitive to etomidate (β2N265S). In Purkinje neurones derived from such mice, the effects of etomidate on inhibitory synaptic transmission are greatly reduced. In complementary behavioural experiments, the mutation influences both the sedative and hypnotic actions of etomidate.

    Original languageEnglish
    Pages (from-to)67-72
    Number of pages6
    JournalInternational Congress Series
    Publication statusPublished - Nov 2005


    • Etomidate
    • GABA
    • GABA receptor
    • General anaesthetic
    • Sedation

    ASJC Scopus subject areas

    • General Medicine


    Dive into the research topics of 'The GABAA receptor: An important target for the general anaesthetic etomidate'. Together they form a unique fingerprint.

    Cite this