The genus Serratia revisited by genomics

David J. Williams, Patrick A. D Grimont, Adrián Cazares, Francine Grimont, Elisabeth Ageron, Kerry A. Pettigrew, Daniel Cazares, Elisabeth Njamkepo, François-Xavier Weill, Eva Heinz, Matthew T. G. Holden, Nicholas R. Thomson (Lead / Corresponding author), Sarah J. Coulthurst (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
91 Downloads (Pure)

Abstract

The genus Serratia has been studied for over a century and includes clinically-important and diverse environmental members. Despite this, there is a paucity of genomic information across the genus and a robust whole genome-based phylogenetic framework is lacking. Here, we have assembled and analysed a representative set of 664 genomes from across the genus, including 215 historic isolates originally used in defining the genus. Phylogenomic analysis of the genus reveals a clearly-defined population structure which displays deep divisions and aligns with ecological niche, as well as striking congruence between historical biochemical phenotyping data and contemporary genomics data. We highlight the genomic, phenotypic and plasmid diversity of Serratia, and provide evidence of different patterns of gene flow across the genus. Our work provides a framework for understanding the emergence of clinical and other lineages of Serratia
Original languageEnglish
Article number5195
Number of pages18
JournalNature Communications
Volume13
DOIs
Publication statusPublished - 3 Sept 2022

Keywords

  • Bacterial evolution
  • Bacterial genomics
  • Pathogens
  • Speciation

ASJC Scopus subject areas

  • General
  • General Physics and Astronomy
  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology

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