The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

Medicine & Life Sciences

• Glutathione Transferase 100%
• Isoenzymes 94%
• Drug Resistance 86%
• Neoplasms 30%
• Glutathione S-Transferase pi 18%
• Enzymes 16%
• glutathione S-transferase alpha 13%
• Xenobiotics 9%
• Transcriptional Activation 7%
• leukotriene-C4 synthase 7%
• Reactive Oxygen Species 6%
• Poisons 6%
• Oxidative Stress 6%
• Plant Cells 5%
• Epoxy Compounds 5%
• Citrus 5%
• Barbiturates 5%
• Peroxides 5%
• Genes 5%
• Membranes 5%
• Gene Amplification 4%
• Environmental Pollutants 4%
• NF-kappa B 4%
• Tumor Cell Line 4%
• Vegetables 4%
• Cytochrome P-450 Enzyme System 4%
• Carcinogens 4%
• Antineoplastic Agents 4%
• Oxidation-Reduction 4%
• Free Radicals 4%
• Glucocorticoids 3%
• Antioxidants 3%
• Phenotype 2%
• Cell Line 2%
• Messenger RNA 2%
• Liver 2%
• In Vitro Techniques 1%
• Pharmaceutical Preparations 1%
• Proteins 1%

Chemical Compounds

• Glutathione 84%
• Inducer 12%
• Oxidative Stress 6%
• Resistance 6%
• Reactive Oxygen Metabolite 6%
• Leukotriene C4 5%
• Barbiturate 4%
• Enhancer 4%
• Xenobiotic Agent 4%
• Detoxification 3%
• Toxic Substance 3%
• Mammalian Cell 3%
• Electrophile 3%
• Antineoplastic Agent 3%
• Cytochrome 3%
• Environmental Pollutant 2%
• Free Radical 2%
• Toxic 2%
• Metabolite 2%
• Drug 1%
• Amount 1%
• Protein 1%