The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21(ras) may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21(ras) in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21(ras) correlated with IL-2 stimulation of T cell proliferation, which indicates that p21(ras) activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21(ras) may play a role in the regulation of T cell growth by IL-2.
|Number of pages||6|
|Journal||Journal of Immunology|
|Publication status||Published - 15 Apr 1992|