Abstract
The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21(ras) may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21(ras) in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21(ras) correlated with IL-2 stimulation of T cell proliferation, which indicates that p21(ras) activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21(ras) may play a role in the regulation of T cell growth by IL-2.
Original language | English |
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Pages (from-to) | 2417-2422 |
Number of pages | 6 |
Journal | Journal of Immunology |
Volume | 148 |
Issue number | 8 |
Publication status | Published - 15 Apr 1992 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology