The growth factor IL-2 activates p21(ras) proteins in normal human T lymphocytes

J. D. Graves, J. Downward, M. Izquierdo-Pastor, S. Rayter, P. H. Warne, D. A. Cantrell

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Abstract

The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21(ras) may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21(ras) in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21(ras) correlated with IL-2 stimulation of T cell proliferation, which indicates that p21(ras) activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21(ras) may play a role in the regulation of T cell growth by IL-2.

Original languageEnglish
Pages (from-to)2417-2422
Number of pages6
JournalJournal of Immunology
Volume148
Issue number8
Publication statusPublished - 15 Apr 1992

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Graves, J. D., Downward, J., Izquierdo-Pastor, M., Rayter, S., Warne, P. H., & Cantrell, D. A. (1992). The growth factor IL-2 activates p21(ras) proteins in normal human T lymphocytes. Journal of Immunology, 148(8), 2417-2422.