The growth factor IL-2 activates p21(ras) proteins in normal human T lymphocytes

J. D. Graves; J. Downward; M. Izquierdo-Pastor; S. Rayter; P. H. Warne; D. A. Cantrell

The growth factor IL-2 activates p21(ras) proteins in normal human T lymphocytes

J. D. Graves
, J. Downward
, M. Izquierdo-Pastor
, S. Rayter
, P. H. Warne
, D. A. Cantrell

Research output: Contribution to journal › Article › peer-review

Abstract

The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21(ras) may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21(ras) in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21(ras) correlated with IL-2 stimulation of T cell proliferation, which indicates that p21(ras) activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21(ras) may play a role in the regulation of T cell growth by IL-2.

Original language	English
Pages (from-to)	2417-2422
Number of pages	6
Journal	Journal of Immunology
Volume	148
Issue number	8
Publication status	Published - 15 Apr 1992

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "The growth factor IL-2 activates p21(ras) proteins in normal human T lymphocytes",

abstract = "The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21(ras) may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21(ras) in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21(ras) correlated with IL-2 stimulation of T cell proliferation, which indicates that p21(ras) activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21(ras) may play a role in the regulation of T cell growth by IL-2.",

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AU - Graves, J. D.

AU - Downward, J.

AU - Izquierdo-Pastor, M.

AU - Rayter, S.

AU - Warne, P. H.

AU - Cantrell, D. A.

PY - 1992/4/15

Y1 - 1992/4/15

N2 - The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21(ras) may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21(ras) in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21(ras) correlated with IL-2 stimulation of T cell proliferation, which indicates that p21(ras) activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21(ras) may play a role in the regulation of T cell growth by IL-2.

AB - The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21(ras) may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21(ras) in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21(ras) correlated with IL-2 stimulation of T cell proliferation, which indicates that p21(ras) activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21(ras) may play a role in the regulation of T cell growth by IL-2.

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UR - http://www.jimmunol.org/content/148/8/2417

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AN - SCOPUS:0026582203

SN - 0022-1767

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SP - 2417

EP - 2422

JO - Journal of Immunology

JF - Journal of Immunology

IS - 8

ER -

The growth factor IL-2 activates p21(ras) proteins in normal human T lymphocytes

Abstract

ASJC Scopus subject areas

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