The Guanidine Riboswitch-A Poor Orphan No Longer

David M. J. Lilley (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Riboswitches are widespread in the bacterial kingdom, where they regulate gene expression in response to different small molecules and ions. However, some remain orphans with no known endogenous ligand. Three recently published papers (Battaglia et al., 2017; Nelson et al., 2017; and Reiss et al., 2017) de-orphanize a widespread ykkC element, showing that it responds to guanidine and elaborating on how that response is mediated.

Original languageEnglish
Pages (from-to)130-131
Number of pages2
JournalCell Chemical Biology
Issue number2
Publication statusPublished - 16 Feb 2017


  • Journal article


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