The Guanidine Riboswitch-A Poor Orphan No Longer

David M. J. Lilley

doi:10.1016/j.chembiol.2017.01.010

The Guanidine Riboswitch-A Poor Orphan No Longer

David M. J. Lilley (Lead / Corresponding author)

Nucleic Acid Structure

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Riboswitches are widespread in the bacterial kingdom, where they regulate gene expression in response to different small molecules and ions. However, some remain orphans with no known endogenous ligand. Three recently published papers (Battaglia et al., 2017; Nelson et al., 2017; and Reiss et al., 2017) de-orphanize a widespread ykkC element, showing that it responds to guanidine and elaborating on how that response is mediated.

Original language	English
Pages (from-to)	130-131
Number of pages	2
Journal	Cell Chemical Biology
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.chembiol.2017.01.010
Publication status	Published - 16 Feb 2017

Keywords

Journal article

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10.1016/j.chembiol.2017.01.010

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2 Finished

Dynamics of Eukaryotic Junction-Resolving Enzyme GEN1 - DNA Junction Interactions
Lilley, D.
Biotechnology and Biological Sciences Research Council
1/10/16 → 30/09/19
Project: Research
Fluorescence Resonance Energy Transfer as a Rich Source of Orientational Information in Nucleic Acid Structure
Lilley, D.
Engineering and Physical Sciences Research Council
1/09/12 → 30/06/16
Project: Research

Cite this

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title = "The Guanidine Riboswitch-A Poor Orphan No Longer",

abstract = "Riboswitches are widespread in the bacterial kingdom, where they regulate gene expression in response to different small molecules and ions. However, some remain orphans with no known endogenous ligand. Three recently published papers (Battaglia et al., 2017; Nelson et al., 2017; and Reiss et al., 2017) de-orphanize a widespread ykkC element, showing that it responds to guanidine and elaborating on how that response is mediated.",

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AB - Riboswitches are widespread in the bacterial kingdom, where they regulate gene expression in response to different small molecules and ions. However, some remain orphans with no known endogenous ligand. Three recently published papers (Battaglia et al., 2017; Nelson et al., 2017; and Reiss et al., 2017) de-orphanize a widespread ykkC element, showing that it responds to guanidine and elaborating on how that response is mediated.

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DO - 10.1016/j.chembiol.2017.01.010

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The Guanidine Riboswitch-A Poor Orphan No Longer

Abstract

Keywords

Access to Document

Dynamics of Eukaryotic Junction-Resolving Enzyme GEN1 - DNA Junction Interactions

Fluorescence Resonance Energy Transfer as a Rich Source of Orientational Information in Nucleic Acid Structure

Cite this