The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors

Sandrine Dufort; Géraldine Le Duc; Murielle Salomé; Valerie Bentivegna; Lucie Sancey; Elke Bräuer-Krisch; Herwig Requardt; François Lux; Jean Luc Coll; Pascal Perriat; Stéphane Roux; Olivier Tillement

doi:10.1038/srep29678

The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors

Sandrine Dufort, Géraldine Le Duc (Lead / Corresponding author), Murielle Salomé, Valerie Bentivegna, Lucie Sancey, Elke Bräuer-Krisch, Herwig Requardt, François Lux, Jean Luc Coll, Pascal Perriat, Stéphane Roux (Lead / Corresponding author), Olivier Tillement

School of Life Sciences

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Abstract

We recently developed the synthesis of ultrasmall gadolinium-based nanoparticles (GBN), (hydrodynamic diameter <5nm) characterized by a safe behavior after intravenous injection (renal clearance, preferential accumulation in tumors). Owing to the presence of gadolinium ions, GBN can be used as contrast agents for magnetic resonance imaging (MRI) and as radiosensitizers. The attempt to determine the most opportune delay between the intravenous injection of GBN and the irradiation showed that a very low content of radiosensitizing nanoparticles in the tumor area is sufficient (0.1μg/g of particles, i.e. 15ppb of gadolinium) for an important increase of the therapeutic effect of irradiation. Such a promising and unexpected result is assigned to a suited distribution of GBN within the tumor, as revealed by the X-ray fluorescence (XRF) maps.

Original language	English
Article number	29678
Number of pages	8
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep29678
Publication status	Published - 14 Jul 2016

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abstract = "We recently developed the synthesis of ultrasmall gadolinium-based nanoparticles (GBN), (hydrodynamic diameter <5nm) characterized by a safe behavior after intravenous injection (renal clearance, preferential accumulation in tumors). Owing to the presence of gadolinium ions, GBN can be used as contrast agents for magnetic resonance imaging (MRI) and as radiosensitizers. The attempt to determine the most opportune delay between the intravenous injection of GBN and the irradiation showed that a very low content of radiosensitizing nanoparticles in the tumor area is sufficient (0.1μg/g of particles, i.e. 15ppb of gadolinium) for an important increase of the therapeutic effect of irradiation. Such a promising and unexpected result is assigned to a suited distribution of GBN within the tumor, as revealed by the X-ray fluorescence (XRF) maps.",

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AU - Dufort, Sandrine

AU - Le Duc, Géraldine

AU - Salomé, Murielle

AU - Bentivegna, Valerie

AU - Sancey, Lucie

AU - Bräuer-Krisch, Elke

AU - Requardt, Herwig

AU - Lux, François

AU - Coll, Jean Luc

AU - Perriat, Pascal

AU - Roux, Stéphane

AU - Tillement, Olivier

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The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors

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