The Human Diabetes Proteome Project (HDPP): The 2014 update

D. Schvartz; P. Bergsten; K. H. Baek; A. Barba De La Rosa; J. Cantley; L. Dayon; F. Finamore; P. Fontana; P. Gaudet; Y. A. Goo; R. Moulder; D. Goodlett; J. D. Johnson; A. Konvalinka; H. Mulderm; F. Priego-Capote; S. Sechi; M. Snyder; A. Tiss; A. Wiederkehr; I. Xenarios; M. Kussmann; Jean-Charles Sanchez

doi:10.1016/j.trprot.2015.03.001

The Human Diabetes Proteome Project (HDPP): The 2014 update

D. Schvartz, P. Bergsten, K. H. Baek, A. Barba De La Rosa, J. Cantley, L. Dayon, F. Finamore, P. Fontana, P. Gaudet, Y. A. Goo, R. Moulder, D. Goodlett, J. D. Johnson, A. Konvalinka, H. Mulderm, F. Priego-Capote, S. Sechi, M. Snyder, A. Tiss, A. WiederkehrI. Xenarios, M. Kussmann, Jean-Charles Sanchez

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Translational Proteomics
Volume	8-9
Early online date	1 Apr 2015
DOIs	https://doi.org/10.1016/j.trprot.2015.03.001
Publication status	Published - 1 Dec 2015

Keywords

B/D-HPP
Blood
Diabetes
HDPP
HPP
Human proteome
Islet
Network biology

ASJC Scopus subject areas

Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trprot.2015.03.001

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Schvartz, D., Bergsten, P., Baek, K. H., De La Rosa, A. B., Cantley, J., Dayon, L., Finamore, F., Fontana, P., Gaudet, P., Goo, Y. A., Moulder, R., Goodlett, D., Johnson, J. D., Konvalinka, A., Mulderm, H., Priego-Capote, F., Sechi, S., Snyder, M., Tiss, A., ... Sanchez, J.-C. (2015). The Human Diabetes Proteome Project (HDPP): The 2014 update. Translational Proteomics, 8-9, 1-7. https://doi.org/10.1016/j.trprot.2015.03.001

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abstract = "Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.",

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Schvartz, D, Bergsten, P, Baek, KH, De La Rosa, AB, Cantley, J, Dayon, L, Finamore, F, Fontana, P, Gaudet, P, Goo, YA, Moulder, R, Goodlett, D, Johnson, JD, Konvalinka, A, Mulderm, H, Priego-Capote, F, Sechi, S, Snyder, M, Tiss, A, Wiederkehr, A, Xenarios, I, Kussmann, M & Sanchez, J-C 2015, 'The Human Diabetes Proteome Project (HDPP): The 2014 update', Translational Proteomics, vol. 8-9, pp. 1-7. https://doi.org/10.1016/j.trprot.2015.03.001

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AU - Baek, K. H.

AU - De La Rosa, A. Barba

AU - Cantley, J.

AU - Dayon, L.

AU - Finamore, F.

AU - Fontana, P.

AU - Gaudet, P.

AU - Goo, Y. A.

AU - Moulder, R.

AU - Goodlett, D.

AU - Johnson, J. D.

AU - Konvalinka, A.

AU - Mulderm, H.

AU - Priego-Capote, F.

AU - Sechi, S.

AU - Snyder, M.

AU - Tiss, A.

AU - Wiederkehr, A.

AU - Xenarios, I.

AU - Kussmann, M.

AU - Sanchez, Jean-Charles

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N2 - Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

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KW - Diabetes

KW - HDPP

KW - HPP

KW - Human proteome

KW - Islet

KW - Network biology

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DO - 10.1016/j.trprot.2015.03.001

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SN - 2212-9626

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JO - Translational Proteomics

JF - Translational Proteomics

ER -

The Human Diabetes Proteome Project (HDPP): The 2014 update

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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