The Human Diabetes Proteome Project (HDPP): The 2014 update

TY - JOUR

T1 - The Human Diabetes Proteome Project (HDPP)

T2 - The 2014 update

AU - Schvartz, D.

AU - Bergsten, P.

AU - Baek, K. H.

AU - De La Rosa, A. Barba

AU - Cantley, J.

AU - Dayon, L.

AU - Finamore, F.

AU - Fontana, P.

AU - Gaudet, P.

AU - Goo, Y. A.

AU - Moulder, R.

AU - Goodlett, D.

AU - Johnson, J. D.

AU - Konvalinka, A.

AU - Mulderm, H.

AU - Priego-Capote, F.

AU - Sechi, S.

AU - Snyder, M.

AU - Tiss, A.

AU - Wiederkehr, A.

AU - Xenarios, I.

AU - Kussmann, M.

AU - Sanchez, Jean-Charles

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

AB - Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

KW - B/D-HPP

KW - Blood

KW - Diabetes

KW - HDPP

KW - HPP

KW - Human proteome

KW - Islet

KW - Network biology

UR - https://www.scopus.com/pages/publications/84994462692

U2 - 10.1016/j.trprot.2015.03.001

DO - 10.1016/j.trprot.2015.03.001

M3 - Article

AN - SCOPUS:84994462692

SN - 2212-9626

VL - 8-9

SP - 1

EP - 7

JO - Translational Proteomics

JF - Translational Proteomics

ER -