The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist

Joseph Rimland, Angela Dunne, Suchete S Hunjan, Rosemary Sasse, Iain Uings, Dino Montanari, Matilde Caivano, Poonam Shah, David Standing, David Gray, David Brown, William Cairns, Ryan Trump, Paul W Smith, Nicolas Bertheleme, Pier D'Alessandro, Sheraz Gul, Mythily Vimal, David N Smith, Stephen P Watson

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    The identification of novel, potent, non-steroidal/small molecule functional GR antagonist GSK1564023A selective over PR is described. Associated structure-activity relationships and the process of optimisation of an initial HTS hit are also described.
    Original languageEnglish
    Pages (from-to)2340-3
    Number of pages4
    JournalBioorganic & Medicinal Chemistry Letters
    Volume20
    Issue number7
    DOIs
    Publication statusPublished - Apr 2010

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