@inbook{d955398a106242569a4147b4b17e4eaf,
title = "The immunology of bronchiectasis",
abstract = "Bronchiectasis is an inflammatory lung disease in which immune dysfunction is both a cause and a consequence of airway damage. The importance of understanding these concepts is underscored by the advent of immunomodulatory therapies for bronchiectasis. This chapter outlines how genetic susceptibility, autoimmune and systemic inflammatory diseases, and the lifetime exposome shape immune processes that drive disease initiation and establish the vicious vortex of mucus obstruction, infection and structural injury. We describe inflammation-driven pathology in established disease, including the central role of neutrophils, alongside eosinophils, macrophages, lymphocytes and epithelial cell injury. The increasingly recognised contribution of systemic inflammation and endothelial dysfunction is discussed, together with heterogeneous immune mechanisms and endotypes of exacerbations, and the frequent-exacerbator phenotype. Finally, we highlight emerging immuno-modulatory targets and emphasise the importance of understanding bronchiectasis immunology for earlier and more effective treatment.",
author = "Chloe Hughes and Lidia Perea and Jennifer Pollock and Long, \{Merete B.\}",
note = "Publisher Copyright: {\textcopyright} ERS 2026.",
year = "2026",
month = mar,
doi = "10.1183/2312508X.10001325",
language = "English",
isbn = "9781849541993",
volume = "2026-March",
series = "ERS Monograph",
publisher = "European Respiratory Society",
pages = "63--83",
editor = "Chalmers, \{James D\} and Amelia Shoemark and Aliberti, \{Stefano \} and Mazzone, \{Stuart B\}",
booktitle = "Brochiectasis",
edition = "111",
}