The impact of compliance during exclusive enteral nutrition on faecal calprotectin in children with Crohn disease

Shona McKirdy, Richard K. Russell, Vaios Svolos, Konstantinos Gkikas, Michael Logan, Richard Hansen, Konstantinos Gerasimidis (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

It remains unclear whether suboptimal response to exclusive enteral nutrition (EEN) in some children with Crohn disease (CD) is explained by poor compliance. The present study measured faecal gluten immunogenic peptides (GIP), a biomarker of gluten intake, in 45 children (3– 17 years) with CD, and explored associations with faecal calprotectin (FC) levels at 33 and 54 days of EEN. FC decreased in patients with undetectable GIP at both 33 and 54 days of EEN (mean decrease, 33 days: −743 mg/kg, 54 days: –1043 mg/kg, P< 0.001) but not in patients who had detectable levels. At EEN completion, patients with undetectable GIP had a lower FC by 717 mg/kg compared with patients with a positive GIP result (P = 0.042) and demonstrated a greater decline from baseline FC (–69% vs +5%, P = 0.011). Poorer response to EEN is explained in part by diminished compliance. Faecal GIP might be useful as proxy biomarker of EEN compliance.
Original languageEnglish
Pages (from-to)801-804
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume74
Issue number6
DOIs
Publication statusPublished - Jun 2022

Keywords

  • adherence
  • biomarkers
  • children
  • exclusive enteral nutrition
  • inflammatory bowel disease

Fingerprint

Dive into the research topics of 'The impact of compliance during exclusive enteral nutrition on faecal calprotectin in children with Crohn disease'. Together they form a unique fingerprint.

Cite this