The impact of hypoglycaemia on quality of life among adults with type 1 diabetes: Results from “YourSAY: Hypoglycaemia”

Hannah Chatwin (Lead / Corresponding author), Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan E. de Galan, Rory J. McCrimmon, Ulrik Pedersen-Bjergaard, Frans Pouwer, Jane Speight, Hypo-RESOLVE Consortium

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)
    83 Downloads (Pure)


    Aims: Research on hypoglycaemia and quality of life (QoL) has focused mostly on severe hypoglycaemia and psychological outcomes, with less known about other aspects of hypoglycaemia (e.g., self-treated episodes) and impacts on other QoL domains (e.g., relationships). Therefore, we examined the impact of all aspects of hypoglycaemia on QoL in adults with type 1 diabetes (T1DM).

    Methods: Participants completed an online survey, including assessment of hypoglycaemia-specific QoL (using the 12-item Hypoglycaemia Impact Profile). Mann-Whitney U tests examined differences in hypoglycaemia-specific QoL by hypoglycaemia frequency, severity, and awareness. Hierarchical linear regression examined associations with QoL.

    Results: Participants were 1028 adults with T1DM (M ± SD age: 47 ± 15 years; diabetes duration: 27 ± 16 years). Severe and self-treated hypoglycaemia and impaired awareness negatively impacted on overall QoL and several QoL domains, including leisure activities, physical health, ability to keep fit/be active, sleep, emotional well-being, spontaneity, independence, work/studies, and dietary freedom. Diabetes distress was most strongly associated with hypoglycaemia-specific QoL, followed by generic emotional well-being, fear of hypoglycaemia, and confidence in managing hypoglycaemia. Hypoglycaemia frequency and awareness were no longer significantly associated with QoL once psychological factors were considered.

    Conclusions: Hypoglycaemia negatively impacts on several QoL domains. Psychological factors supersede the effect of hypoglycaemia frequency and awareness in accounting for this negative impact.

    Original languageEnglish
    Article number108232
    Number of pages9
    JournalJournal of Diabetes and its Complications
    Issue number11
    Early online date21 Jun 2022
    Publication statusPublished - Nov 2023


    • Hypoglycaemia
    • Quality of life
    • T1DM
    • Well-being
    • Fear of hypoglycaemia
    • Psychological functioning

    ASJC Scopus subject areas

    • Endocrinology
    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism


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