The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

Sara Carucci; Alessandro Zuddas; Angelico Lampis; Kenneth K. C. Man; Carla Balia; Jan Buitelaar; Marina Danckaerts; Ralf W. Dittmann; Federica Donno; Bruno Falissard; Antonella Gagliano; Peter Garas; Alexander Häge; Chris Hollis; Sarah K. Inglis; Kerstin Konrad; Hanna Kovshoff; Elizabeth Liddle; Suzanne McCarthy; Antje Neubert; Peter Nagy; Eric Rosenthal; Edmund J. S. Sonuga-Barke; Ian C. K. Wong; Tobias Banaschewski; David Coghill; The ADDUCE Consortium

doi:10.1177/10870547241226726

The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

Sara Carucci (Lead / Corresponding author), Alessandro Zuddas, Angelico Lampis, Kenneth K. C. Man, Carla Balia, Jan Buitelaar, Marina Danckaerts, Ralf W. Dittmann, Federica Donno, Bruno Falissard, Antonella Gagliano, Peter Garas, Alexander Häge, Chris Hollis, Sarah K. Inglis, Kerstin Konrad, Hanna Kovshoff, Elizabeth Liddle, Suzanne McCarthy, Antje NeubertPeter Nagy, Eric Rosenthal, Edmund J. S. Sonuga-Barke, Ian C. K. Wong, Tobias Banaschewski, David Coghill, The ADDUCE Consortium

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Abstract

Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.

Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.

Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.

Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

Original language	English
Pages (from-to)	722-739
Number of pages	18
Journal	Journal of Attention Disorders
Volume	28
Issue number	5
Early online date	17 Feb 2024
DOIs	https://doi.org/10.1177/10870547241226726
Publication status	Published - Mar 2024

Keywords

ADHD
methylphenidate
growth
pubertal maturation
bone age

ASJC Scopus subject areas

Clinical Psychology
Developmental and Educational Psychology

Access to Document

10.1177/10870547241226726

Author Accepted ManuscriptAccepted author manuscript, 579 KB

Cite this

Carucci, S., Zuddas, A., Lampis, A., Man, K. K. C., Balia, C., Buitelaar, J., Danckaerts, M., Dittmann, R. W., Donno, F., Falissard, B., Gagliano, A., Garas, P., Häge, A., Hollis, C., Inglis, S. K., Konrad, K., Kovshoff, H., Liddle, E., McCarthy, S., ... The ADDUCE Consortium (2024). The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project. Journal of Attention Disorders, 28(5), 722-739. https://doi.org/10.1177/10870547241226726

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title = "The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project",

abstract = "Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.",

keywords = "ADHD, methylphenidate, growth, pubertal maturation, bone age",

author = "Sara Carucci and Alessandro Zuddas and Angelico Lampis and Man, {Kenneth K. C.} and Carla Balia and Jan Buitelaar and Marina Danckaerts and Dittmann, {Ralf W.} and Federica Donno and Bruno Falissard and Antonella Gagliano and Peter Garas and Alexander H{\"a}ge and Chris Hollis and Inglis, {Sarah K.} and Kerstin Konrad and Hanna Kovshoff and Elizabeth Liddle and Suzanne McCarthy and Antje Neubert and Peter Nagy and Eric Rosenthal and Sonuga-Barke, {Edmund J. S.} and Wong, {Ian C. K.} and Tobias Banaschewski and David Coghill and {The ADDUCE Consortium}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = mar,

doi = "10.1177/10870547241226726",

language = "English",

volume = "28",

pages = "722--739",

journal = "Journal of Attention Disorders",

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Carucci, S, Zuddas, A, Lampis, A, Man, KKC, Balia, C, Buitelaar, J, Danckaerts, M, Dittmann, RW, Donno, F, Falissard, B, Gagliano, A, Garas, P, Häge, A, Hollis, C, Inglis, SK, Konrad, K, Kovshoff, H, Liddle, E, McCarthy, S, Neubert, A, Nagy, P, Rosenthal, E, Sonuga-Barke, EJS, Wong, ICK, Banaschewski, T, Coghill, D & The ADDUCE Consortium 2024, 'The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project', Journal of Attention Disorders, vol. 28, no. 5, pp. 722-739. https://doi.org/10.1177/10870547241226726

The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project. / Carucci, Sara (Lead / Corresponding author); Zuddas, Alessandro; Lampis, Angelico et al.
In: Journal of Attention Disorders, Vol. 28, No. 5, 03.2024, p. 722-739.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents

T2 - Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

AU - Carucci, Sara

AU - Zuddas, Alessandro

AU - Lampis, Angelico

AU - Man, Kenneth K. C.

AU - Balia, Carla

AU - Buitelaar, Jan

AU - Danckaerts, Marina

AU - Dittmann, Ralf W.

AU - Donno, Federica

AU - Falissard, Bruno

AU - Gagliano, Antonella

AU - Garas, Peter

AU - Häge, Alexander

AU - Hollis, Chris

AU - Inglis, Sarah K.

AU - Konrad, Kerstin

AU - Kovshoff, Hanna

AU - Liddle, Elizabeth

AU - McCarthy, Suzanne

AU - Neubert, Antje

AU - Nagy, Peter

AU - Rosenthal, Eric

AU - Sonuga-Barke, Edmund J. S.

AU - Wong, Ian C. K.

AU - Banaschewski, Tobias

AU - Coghill, David

AU - The ADDUCE Consortium

PY - 2024/3

Y1 - 2024/3

N2 - Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

AB - Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

KW - ADHD

KW - methylphenidate

KW - growth

KW - pubertal maturation

KW - bone age

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DO - 10.1177/10870547241226726

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SN - 1087-0547

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The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

Abstract

Keywords

ASJC Scopus subject areas

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Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE) (joint with 13 other partners)

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The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE) (joint with 13 other partners)

Cite this