The induction of gene expression in mammalian cells by radiation

    Research output: Contribution to journalArticlepeer-review

    75 Citations (Scopus)


    A large number of genes have now been shown to be inducible in response to radiation in mammalian cells and tissues. Based on extensive studies of stress inducible regulons in bacteria, it is assumed that at least some of the proteins encoded by these genes are involved in an adaptive response to the lethal effects of radiation. Here I review the biological evidence for adaptation, and analyse the functions of radiation inducible genes in the context of their possible roles in cellular protection. Recent progress has been made in understanding how cells sense radiation induced damage. The signal transduction pathways which end in the activation of specific genes is summarized.
    Original languageEnglish
    Pages (from-to)119-28
    Number of pages10
    JournalSeminars in Cancer Biology
    Issue number2
    Publication statusPublished - 1993


    Dive into the research topics of 'The induction of gene expression in mammalian cells by radiation'. Together they form a unique fingerprint.

    Cite this