The inhibitory effect of phospholemman on the sodium pump requires Its palmitoylation

Lindsay B. Tulloch; Jacqueline Howie; Krzysztof J. Wypijewski; Catherine R. Wilson; William G. Bernard; Michael J. Shattock; William Fuller

doi:10.1074/jbc.M111.282145

The inhibitory effect of phospholemman on the sodium pump requires Its palmitoylation

Lindsay B. Tulloch, Jacqueline Howie, Krzysztof J. Wypijewski, Catherine R. Wilson, William G. Bernard, Michael J. Shattock, William Fuller (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.

Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.

Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.

Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

Original language	English
Pages (from-to)	36020-36031
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	286
Issue number	41
Early online date	25 Aug 2011
DOIs	https://doi.org/10.1074/jbc.M111.282145
Publication status	Published - 14 Oct 2011

Keywords

Heart
Na,K-ATPase
Protein acylation
Protein palmitoylation
Protein phosphorylation
FXYD
Phospholemman

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10.1074/jbc.M111.282145

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title = "The inhibitory effect of phospholemman on the sodium pump requires Its palmitoylation",

abstract = "Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.",

keywords = "Heart, Na,K-ATPase, Protein acylation, Protein palmitoylation, Protein phosphorylation, FXYD, Phospholemman",

author = "Tulloch, {Lindsay B.} and Jacqueline Howie and Wypijewski, {Krzysztof J.} and Wilson, {Catherine R.} and Bernard, {William G.} and Shattock, {Michael J.} and William Fuller",

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AU - Tulloch, Lindsay B.

AU - Howie, Jacqueline

AU - Wypijewski, Krzysztof J.

AU - Wilson, Catherine R.

AU - Bernard, William G.

AU - Shattock, Michael J.

AU - Fuller, William

PY - 2011/10/14

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N2 - Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

AB - Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

KW - Heart

KW - Na,K-ATPase

KW - Protein acylation

KW - Protein palmitoylation

KW - Protein phosphorylation

KW - FXYD

KW - Phospholemman

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EP - 36031

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 41

ER -

The inhibitory effect of phospholemman on the sodium pump requires Its palmitoylation

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Keywords

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