Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.
Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.
Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.
Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.
- Protein acylation
- Protein palmitoylation
- Protein phosphorylation