The inhibitory effect of phospholemman on the sodium pump requires Its palmitoylation

Lindsay B. Tulloch, Jacqueline Howie, Krzysztof J. Wypijewski, Catherine R. Wilson, William G. Bernard, Michael J. Shattock, William Fuller (Lead / Corresponding author)

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    Abstract

    Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.

    Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.

    Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.

    Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

    Original languageEnglish
    Pages (from-to)36020-36031
    Number of pages12
    JournalJournal of Biological Chemistry
    Volume286
    Issue number41
    Early online date25 Aug 2011
    DOIs
    Publication statusPublished - 14 Oct 2011

    Keywords

    • Heart
    • Na,K-ATPase
    • Protein acylation
    • Protein palmitoylation
    • Protein phosphorylation
    • FXYD
    • Phospholemman

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