The inhibitory effect of phospholemman on the sodium pump requires Its palmitoylation

TY - JOUR

T1 - The inhibitory effect of phospholemman on the sodium pump requires Its palmitoylation

AU - Tulloch, Lindsay B.

AU - Howie, Jacqueline

AU - Wypijewski, Krzysztof J.

AU - Wilson, Catherine R.

AU - Bernard, William G.

AU - Shattock, Michael J.

AU - Fuller, William

PY - 2011/10/14

Y1 - 2011/10/14

N2 - Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

AB - Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart.Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump.Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump.Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

KW - Heart

KW - Na,K-ATPase

KW - Protein acylation

KW - Protein palmitoylation

KW - Protein phosphorylation

KW - FXYD

KW - Phospholemman

UR - https://www.scopus.com/pages/publications/80053897407

U2 - 10.1074/jbc.M111.282145

DO - 10.1074/jbc.M111.282145

M3 - Article

C2 - 21868384

SN - 0021-9258

VL - 286

SP - 36020

EP - 36031

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 41

ER -