The inhibitory effects of local anaesthetics on the vascular flare responses to bradykinin and substance P in human skin

M. P. Dias, D. J. Newton, G. A. McLeod, F. Khan, J. J. F. Belch

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    Bradykinin and substance P are involved in inflammation and act through Gq-protein-coupled receptors. Local anaesthetics inhibit the signalling of these receptors and have potent anti-inflammatory actions. The aim of this study was to investigate the effects of local anaesthetics on the cutaneous flare responses to bradykinin and substance P. Skin blood flow responses to intradermal injections of bradykinin and substance P were assessed in the absence and presence of anaesthetic and analgesic concentrations of lidocaine, levobupivacaine and ropivacame. All local anaesthetics significantly attenuated the vascular responses to bradykinin (p = 0.001) and substance P (p < 0.001). There were no differences in this effect between the different agents, but anaesthetic concentrations had a greater attenuating effect than analgesic concentrations on the substance P response (p < 0.001). Local anaesthetics may therefore be useful in the suppression of inflammation and the prevention of postoperative hyperalgesia.

    Original languageEnglish
    Pages (from-to)151-155
    Number of pages5
    JournalAnaesthesia
    Volume63
    Issue number2
    DOIs
    Publication statusPublished - Feb 2008

    Keywords

    • Adult
    • Amides
    • Anesthetics, Local
    • Bradykinin
    • Bupivacaine
    • Double-Blind Method
    • Humans
    • Laser-Doppler Flowmetry
    • Lidocaine
    • Male
    • Regional Blood Flow
    • Skin
    • Substance P
    • Vasodilator Agents

    Cite this

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    abstract = "Bradykinin and substance P are involved in inflammation and act through Gq-protein-coupled receptors. Local anaesthetics inhibit the signalling of these receptors and have potent anti-inflammatory actions. The aim of this study was to investigate the effects of local anaesthetics on the cutaneous flare responses to bradykinin and substance P. Skin blood flow responses to intradermal injections of bradykinin and substance P were assessed in the absence and presence of anaesthetic and analgesic concentrations of lidocaine, levobupivacaine and ropivacame. All local anaesthetics significantly attenuated the vascular responses to bradykinin (p = 0.001) and substance P (p < 0.001). There were no differences in this effect between the different agents, but anaesthetic concentrations had a greater attenuating effect than analgesic concentrations on the substance P response (p < 0.001). Local anaesthetics may therefore be useful in the suppression of inflammation and the prevention of postoperative hyperalgesia.",
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    The inhibitory effects of local anaesthetics on the vascular flare responses to bradykinin and substance P in human skin. / Dias, M. P.; Newton, D. J.; McLeod, G. A.; Khan, F.; Belch, J. J. F.

    In: Anaesthesia, Vol. 63, No. 2, 02.2008, p. 151-155.

    Research output: Contribution to journalArticle

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