The interaction of parameters of male and female fertility in couples with previously unexplained infertility

Bruce C. Dunphy, Tin-Chiu Li, Iona C. Macleod, Christopher L. R. Barratt, Elizabeth A. Lenton, Ian D. Cooke

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


A prospective study was undertaken of the relationship between semen variables, serial endocrine and follicular ultrasound measurements in one complete menstrual cycle, and the treatment-independent chance of conception for couples who were referred with unexplained infertility. For the 91 couples studied, the mean length of infertility was 70 months. A 100% follow-up rate was achieved. When a stepwise analysis was performed examining semen variables and ultrasonographic and endocrine variables, the mean ratio of salivary progesterone/plasma estradiol between days +1 and +3, with respect to the luteinizing hormone surge and the Grade 2 motile sperm density, were the only variables that achieved the 5% level of significance. There was a highly significant relationship between the product of these two variables and the chance of conception. This study clearly demonstrates an interaction between parameters of male and female fertility.

Original languageEnglish
Pages (from-to)824-827
Number of pages4
JournalFertility and Sterility
Issue number5
Publication statusPublished - Nov 1990


  • Estradiol/blood
  • Female
  • Fertility/physiology
  • Follow-Up Studies
  • Gonadotropins/blood
  • Humans
  • Infertility/epidemiology
  • Luteinizing Hormone/blood
  • Male
  • Menstrual Cycle/physiology
  • Ovarian Follicle/diagnostic imaging
  • Progesterone/analysis
  • Prospective Studies
  • Saliva/chemistry
  • Semen/physiology
  • Sperm Motility/physiology
  • Ultrasonography


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