The interferon response to intracellular DNA: Why so many receptors?

Leonie Unterholzner

    Research output: Contribution to journalArticlepeer-review

    159 Citations (Scopus)

    Abstract

    The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA.
    Original languageEnglish
    Pages (from-to)1312-1321
    Number of pages10
    JournalImmunobiology
    Volume218
    Issue number11
    DOIs
    Publication statusPublished - Nov 2013

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