The interferon response to intracellular DNA: Why so many receptors?

Leonie Unterholzner

doi:10.1016/j.imbio.2013.07.007

The interferon response to intracellular DNA: Why so many receptors?

Leonie Unterholzner

Research output: Contribution to journal › Article › peer-review

213 Citations (Scopus)

Abstract

The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA.

Original language	English
Pages (from-to)	1312-1321
Number of pages	10
Journal	Immunobiology
Volume	218
Issue number	11
DOIs	https://doi.org/10.1016/j.imbio.2013.07.007
Publication status	Published - Nov 2013

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10.1016/j.imbio.2013.07.007

Elucidating the Molecular Mechanism of Intracellular DNA Recognition by the Innate Immune Sensor IFI16 (Career Development Fellowship)
Unterholzner, L. (Investigator) & Watts, C. (Investigator)
Medical Research Council
1/02/13 → 31/01/18
Project: Research

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title = "The interferon response to intracellular DNA: Why so many receptors?",

abstract = "The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA.",

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The interferon response to intracellular DNA: Why so many receptors?

Abstract

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Elucidating the Molecular Mechanism of Intracellular DNA Recognition by the Innate Immune Sensor IFI16 (Career Development Fellowship)

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