The interleukin-2 T-cell system: A new cell growth model

Doreen A. Cantrell, Kendall A. Smith

Research output: Contribution to journalArticle

694 Citations (Scopus)

Abstract

Synchronized interleukin-2 receptor-positive T cells, homogeneous immunoaffinity-purified interleukin-2, and a monoclonal antibody to interleukin-2 receptors were used to show that only three factors are critical for T-cell cycle progression: interleukin-2 concentration, interleukin-2 receptor density, and the duration of the interleukin-2 receptor interaction. Since the proliferative characteristics of T cells are identical to those of both prokaryotic and all other eukaryotic cells, these findings provide a new model that accounts fully for the variables that determine cell cycle progression.

Original languageEnglish
Pages (from-to)1312-1316
Number of pages5
JournalScience
Volume224
Issue number4655
DOIs
Publication statusPublished - 22 Jun 1984

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