The interleukin-2 T-cell system: A new cell growth model

TY - JOUR

T1 - The interleukin-2 T-cell system

T2 - A new cell growth model

AU - Cantrell, Doreen A.

AU - Smith, Kendall A.

PY - 1984/6/22

Y1 - 1984/6/22

N2 - Synchronized interleukin-2 receptor-positive T cells, homogeneous immunoaffinity-purified interleukin-2, and a monoclonal antibody to interleukin-2 receptors were used to show that only three factors are critical for T-cell cycle progression: interleukin-2 concentration, interleukin-2 receptor density, and the duration of the interleukin-2 receptor interaction. Since the proliferative characteristics of T cells are identical to those of both prokaryotic and all other eukaryotic cells, these findings provide a new model that accounts fully for the variables that determine cell cycle progression.

AB - Synchronized interleukin-2 receptor-positive T cells, homogeneous immunoaffinity-purified interleukin-2, and a monoclonal antibody to interleukin-2 receptors were used to show that only three factors are critical for T-cell cycle progression: interleukin-2 concentration, interleukin-2 receptor density, and the duration of the interleukin-2 receptor interaction. Since the proliferative characteristics of T cells are identical to those of both prokaryotic and all other eukaryotic cells, these findings provide a new model that accounts fully for the variables that determine cell cycle progression.

UR - https://www.scopus.com/pages/publications/0021271862

U2 - 10.1126/science.6427923

DO - 10.1126/science.6427923

M3 - Article

C2 - 6427923

AN - SCOPUS:0021271862

SN - 0036-8075

VL - 224

SP - 1312

EP - 1316

JO - Science

JF - Science

IS - 4655

ER -