The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts

Jens Januschke, Cayetano Gonzalez (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    66 Citations (Scopus)

    Abstract

    The mechanisms that maintain the orientation of cortical polarity and asymmetric division unchanged in consecutive mitoses in Drosophila melanogaster neuroblasts (NBs) are unknown. By studying the effect of transient microtubule depolymerization and centrosome mutant conditions, we have found that such orientation memory requires both the centrosome-organized interphase aster and centrosome-independent functions. We have also found that the span of such memory is limited to the last mitosis. Furthermore, the orientation of the NB axis of polarity can be reset to any angle with respect to the surrounding tissue and is, therefore, cell autonomous.
    Original languageEnglish
    Pages (from-to)693-706
    Number of pages14
    JournalJournal of Cell Biology
    Volume188
    Issue number5
    DOIs
    Publication statusPublished - 2010

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