TY - JOUR
T1 - The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts
AU - Januschke, Jens
AU - Gonzalez, Cayetano
PY - 2010
Y1 - 2010
N2 - The mechanisms that maintain the orientation of cortical polarity and asymmetric division unchanged in consecutive mitoses in Drosophila melanogaster neuroblasts (NBs) are unknown. By studying the effect of transient microtubule depolymerization and centrosome mutant conditions, we have found that such orientation memory requires both the centrosome-organized interphase aster and centrosome-independent functions. We have also found that the span of such memory is limited to the last mitosis. Furthermore, the orientation of the NB axis of polarity can be reset to any angle with respect to the surrounding tissue and is, therefore, cell autonomous.
AB - The mechanisms that maintain the orientation of cortical polarity and asymmetric division unchanged in consecutive mitoses in Drosophila melanogaster neuroblasts (NBs) are unknown. By studying the effect of transient microtubule depolymerization and centrosome mutant conditions, we have found that such orientation memory requires both the centrosome-organized interphase aster and centrosome-independent functions. We have also found that the span of such memory is limited to the last mitosis. Furthermore, the orientation of the NB axis of polarity can be reset to any angle with respect to the surrounding tissue and is, therefore, cell autonomous.
UR - http://www.scopus.com/inward/record.url?scp=77949411323&partnerID=8YFLogxK
U2 - 10.1083/jcb.200905024
DO - 10.1083/jcb.200905024
M3 - Article
C2 - 20194641
SN - 1540-8140
VL - 188
SP - 693
EP - 706
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 5
ER -