The intertwined roles of specialized metabolites within the Bacillus subtilis biofilm

Margarita Kalamara; Nicola R. Stanley-Wall

doi:10.1128/JB.00431-21

The intertwined roles of specialized metabolites within the Bacillus subtilis biofilm

Margarita Kalamara, Nicola R. Stanley-Wall (Lead / Corresponding author)

Molecular Microbiology

Research output: Contribution to journal › Comment/debate › peer-review

5 Citations (Scopus)

99 Downloads (Pure)

Abstract

Bacteria produce specialized metabolites with a range of functions. In this issue of the Journal of Bacteriology, Schoenborn et al. study the production and role of secondary metabolites during biofilm development and sporulation in Bacillus subtilis (A. A. Schoenborn, S. M. Yannarell, E. D. Wallace, H. Clapper, et al., J Bacteriol 203:e00337-21, 2021, https://doi.org/https://doi.org/10.1128/JB.00337 -21). Most metabolites studied are produced during differentiation, and six are required for the development of biofilms and/or spores. The authors propose a model for the timing of production and role in differentiation exerted by each secondary metabolite.

Original language	English
Article number	e00431-21
Number of pages	12
Journal	Journal of Bacteriology
Volume	203
Issue number	22
Early online date	30 Aug 2021
DOIs	https://doi.org/10.1128/JB.00431-21
Publication status	Published - 25 Oct 2021

Keywords

Bacillus subtilis
Biofilm
Differentiation
Specialized metabolites
Spore

ASJC Scopus subject areas

Microbiology
Molecular Biology

Access to Document

10.1128/JB.00431-21

Author Accepted ManuscriptAccepted author manuscript, 161 KB
FiguresAccepted author manuscript, 134 KB

Cite this

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title = "The intertwined roles of specialized metabolites within the Bacillus subtilis biofilm",

abstract = "Bacteria produce specialized metabolites with a range of functions. In this issue of the Journal of Bacteriology, Schoenborn et al. study the production and role of secondary metabolites during biofilm development and sporulation in Bacillus subtilis (A. A. Schoenborn, S. M. Yannarell, E. D. Wallace, H. Clapper, et al., J Bacteriol 203:e00337-21, 2021, https://doi.org/https://doi.org/10.1128/JB.00337 -21). Most metabolites studied are produced during differentiation, and six are required for the development of biofilms and/or spores. The authors propose a model for the timing of production and role in differentiation exerted by each secondary metabolite.",

keywords = "Bacillus subtilis, Biofilm, Differentiation, Specialized metabolites, Spore",

author = "Margarita Kalamara and Stanley-Wall, {Nicola R.}",

note = "Biofilm related work in the laboratory of N.R.S.-W. is funded by the Biotechnology and Biological Science Research Council (BBSRC) [BB/P001335/1 and BB/R012415/1]. M.K. is supported by a Biotechnology and Biological Sciences Research Council studentship [BB/M010996/1].",

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AU - Kalamara, Margarita

AU - Stanley-Wall, Nicola R.

N1 - Biofilm related work in the laboratory of N.R.S.-W. is funded by the Biotechnology and Biological Science Research Council (BBSRC) [BB/P001335/1 and BB/R012415/1]. M.K. is supported by a Biotechnology and Biological Sciences Research Council studentship [BB/M010996/1].

PY - 2021/10/25

Y1 - 2021/10/25

N2 - Bacteria produce specialized metabolites with a range of functions. In this issue of the Journal of Bacteriology, Schoenborn et al. study the production and role of secondary metabolites during biofilm development and sporulation in Bacillus subtilis (A. A. Schoenborn, S. M. Yannarell, E. D. Wallace, H. Clapper, et al., J Bacteriol 203:e00337-21, 2021, https://doi.org/https://doi.org/10.1128/JB.00337 -21). Most metabolites studied are produced during differentiation, and six are required for the development of biofilms and/or spores. The authors propose a model for the timing of production and role in differentiation exerted by each secondary metabolite.

AB - Bacteria produce specialized metabolites with a range of functions. In this issue of the Journal of Bacteriology, Schoenborn et al. study the production and role of secondary metabolites during biofilm development and sporulation in Bacillus subtilis (A. A. Schoenborn, S. M. Yannarell, E. D. Wallace, H. Clapper, et al., J Bacteriol 203:e00337-21, 2021, https://doi.org/https://doi.org/10.1128/JB.00337 -21). Most metabolites studied are produced during differentiation, and six are required for the development of biofilms and/or spores. The authors propose a model for the timing of production and role in differentiation exerted by each secondary metabolite.

KW - Bacillus subtilis

KW - Biofilm

KW - Differentiation

KW - Specialized metabolites

KW - Spore

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M3 - Comment/debate

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SN - 0021-9193

VL - 203

JO - Journal of Bacteriology

JF - Journal of Bacteriology

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M1 - e00431-21

ER -

The intertwined roles of specialized metabolites within the Bacillus subtilis biofilm

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

IKC Biofilms (Collaboration with University of Southampton via University of Edinburgh)

Architecture of a Biofilm (Joint with University of Edinburgh)

Bacillus subtilis biofilms and intra-species interactions

Cite this

The intertwined roles of specialized metabolites within the Bacillus subtilis biofilm

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

IKC Biofilms (Collaboration with University of Southampton via University of Edinburgh)

Architecture of a Biofilm (Joint with University of Edinburgh)

Student theses

Bacillus subtilis biofilms and intra-species interactions

Cite this