The involvement of N-methyl-d-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle

Volker Neugebauer, Thomas Lücke, Blair Grubb, Hans Georg Schaible (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    Unilateral adjuvant inflammation was induced at the rat ankle 2 or 20 days before an evaluation of the contribution of N-methyl-d-aspartate (NMDA) and non-NMDA receptors to the processing of nociceptive information by wide dynamic range neurons in the spinal cord. Microionophoretic application of either the NMDA receptor antagonists ketamine and DL-2-amino-5-phosphonovalerate (AP5) or the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced the responses to innocuous and noxious mechanical stimulation of the inflamed ankle. The pattern of these effects was comparable to that in rats with acute inflammation suggesting that non-NMDA and NMDA receptors are similarly involved in acute, prolonged acute and chronic inflammation-evoked activity.

    Original languageEnglish
    Pages (from-to)237-240
    Number of pages4
    JournalNeuroscience Letters
    Volume170
    Issue number2
    DOIs
    Publication statusPublished - 11 Apr 1994

    Keywords

    • AP5
    • Arthritis
    • CNQX
    • Joint nociception
    • Ketamine
    • NMDA receptor antagonist
    • Non-NMDA receptor antagonist
    • Rat spinal cord

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